Gatling W, Mullee M A, Knight C, Hill R D
Poole General Hospital, Dorset, UK.
Diabet Med. 1988 May-Jun;5(4):348-51. doi: 10.1111/j.1464-5491.1988.tb01003.x.
A single observer reviewed 842 of the 917 known diabetic patients registered with 40 GPs in the Poole area. Fifty-nine per cent (493) of those reviewed submitted a timed overnight urine collection to measure albumin excretion rate (AER) and overnight albumin/creatinine ratio (ON-Alb/Creat); 43 samples were excluded because of urinary tract infection and/or proteinuria. A random urine sample was obtained in 607 diabetic patients to measure the random albumin/creatinine ratio (R-Alb/Creat); 68 specimens were excluded because of infection and/or proteinuria, and in a further 10 samples urinary creatinine was not measured. Stepwise multiple regression analyses found significant associations with the following variables: for AER, blood glucose (p = 0.001), smoking category (p = 0.002), sex (p = 0.034), and systolic blood pressure (p = 0.035); for R-Alb/Creat, blood glucose (p = 0.001), retinopathy (p = 0.004), systolic blood pressure (p = 0.004), diastolic blood pressure (p = 0.015), coronary artery disease (p = 0.02), sex (p = 0.034), and vibration sense (p = 0.038). Interestingly, glycosylated haemoglobin was not a significant determinant of albuminuria in either analysis.
一名观察者对普尔地区40名全科医生登记的917名已知糖尿病患者中的842名进行了评估。接受评估的患者中有59%（493名）提交了定时过夜尿液样本，以测量白蛋白排泄率（AER）和过夜白蛋白/肌酐比值（ON-Alb/Creat）；43份样本因尿路感染和/或蛋白尿被排除。607名糖尿病患者采集了随机尿样，以测量随机白蛋白/肌酐比值（R-Alb/Creat）；68份标本因感染和/或蛋白尿被排除，另有10份样本未测量尿肌酐。逐步多元回归分析发现与以下变量存在显著关联：对于AER，血糖（p = 0.001）、吸烟类别（p = 0.002）、性别（p = 0.034）和收缩压（p = 0.035）；对于R-Alb/Creat，血糖（p = 0.001）、视网膜病变（p = 0.004）、收缩压（p = 0.004）、舒张压（p = 0.015）、冠状动脉疾病（p = 0.02）、性别（p = 0.034）和振动觉（p = 0.038）。有趣的是，在两项分析中糖化血红蛋白均不是蛋白尿的显著决定因素。
