Erasmus R T, Oyeyinka G, Arije A
Department of Chemical Pathology & Immunology, University of Ilorin, Nigeria.
Postgrad Med J. 1992 Aug;68(802):638-42. doi: 10.1136/pgmj.68.802.638.
Twenty-four hour urinary albumin concentrations were measured in 113 (mean age 51.1 years) non-insulin-dependent (NIDDM) Nigerian diabetics (50 males, 63 females). A high prevalence of microalbuminuria (> or = 30 mg/24 hour) was observed in male (54%) as well as female diabetics (59%). Microalbuminuria was also observed in a high proportion of diabetics (52%) with a short duration (< 5 years) of disease. Elevated blood pressure and retinopathy were present in 41% and 16% of patients respectively. Among the 49 patients with normoalbuminuria (< 30 mg/24 hour), six (12%) had retinopathy compared with 12 (18%) in the microalbuminuria group. Diastolic blood pressure levels were significantly higher (P < 0.01) in male diabetics with retinopathy but this was not associated with higher albuminuria. Urinary albumin concentrations were not influenced by elevated blood pressure. There were no significant differences in age, duration of diabetes, blood pressure or serum creatinine between diabetics with and without microalbuminuria. These results suggest that though there is a high prevalence of microalbuminuria amongst NIDDM Nigerian diabetics it may not predict retinopathy and occurs independently of either glycaemic control or elevated blood pressure levels.
对113名（平均年龄51.1岁）非胰岛素依赖型（NIDDM）尼日利亚糖尿病患者（50名男性，63名女性）进行了24小时尿白蛋白浓度检测。男性（54%）和女性糖尿病患者（59%）中均观察到微量白蛋白尿（≥30毫克/24小时）的高患病率。在病程较短（<5年）的糖尿病患者中，也有很大比例（52%）出现微量白蛋白尿。分别有41%和16%的患者存在血压升高和视网膜病变。在49名尿白蛋白正常（<30毫克/24小时）的患者中，有6名（12%）患有视网膜病变，而微量白蛋白尿组为12名（18%）。患有视网膜病变的男性糖尿病患者舒张压水平显著更高（P<0.01），但这与更高的蛋白尿无关。尿白蛋白浓度不受血压升高的影响。有微量白蛋白尿和无微量白蛋白尿的糖尿病患者在年龄、糖尿病病程、血压或血清肌酐方面无显著差异。这些结果表明，尽管在尼日利亚NIDDM糖尿病患者中微量白蛋白尿的患病率很高，但它可能无法预测视网膜病变，且其发生与血糖控制或血压升高无关。
