Nikonova T V, Draudin-Krylenko V A, Bukin Iu V, Turusov V S
Eksp Onkol. 1988;10(2):17-9.
It is shown that at the initiating stage of procarbazine carcinogenesis in F1 female mice the parenteral administration of nicotinamide or pyridoxine results in a significant decrease in the lung adenoma rate from 77% to 18 or 46%, respectively. Pyridoxal, pyridoxal-5'-phosphate and L-penicillamine did not influence the lung adenoma frequency.
结果表明，在F1雌性小鼠丙卡巴肼致癌作用的起始阶段，肠胃外给予烟酰胺或吡哆醇可使肺腺瘤发生率显著降低，分别从77%降至18%或46%。吡哆醛、磷酸吡哆醛和L-青霉胺对肺腺瘤发生率无影响。
