Kryzhanovskiĭ G N, Shandra A A, Godlevskiĭ L S
Biull Eksp Biol Med. 1984 Aug;98(8):150-3.
It has been shown in experiments on mice and rats that daily administration of subthreshold doses of pentylenetetrazol led to a progressive increase in the sensitivity to the action of the epileptogen, augmentation of brain epileptization and development of the pharmacological kindling. Single administration of nicotinamide in doses of 250, 500 and 1000 mg/kg and alpha-tocopherol in a dose of 100 mg/kg exerted a pronounced antiepileptic effect under the conditions of over kindling. On combined use of nicotinamide and pyridoxal-5-phosphate, nicotinamide, pyridoxal-5-phosphate and alpha-tocopherol the antiepileptic action was more demonstrable. Daily administration of a complex of the drugs (nicotinamide, pyridoxal-5-phosphate, alpha-tocopherol) produced a substantial reduction in epileptic activity under the conditions of overt kindling. The possibility has been demonstrated of preventing the development of epileptic activity with nicotinamide under kindling.
在对小鼠和大鼠的实验中已表明，每日给予阈下剂量的戊四氮会导致对致痫原作用的敏感性逐渐增加、脑癫痫化增强以及药理学点燃的发展。在过度点燃的情况下，单次给予250、500和1000mg/kg剂量的烟酰胺以及100mg/kg剂量的α-生育酚具有明显的抗癫痫作用。在联合使用烟酰胺和磷酸吡哆醛、烟酰胺、磷酸吡哆醛和α-生育酚时，抗癫痫作用更明显。每日给予药物复合物（烟酰胺、磷酸吡哆醛、α-生育酚）在明显点燃的情况下可使癫痫活动大幅降低。已证明在点燃过程中烟酰胺有预防癫痫活动发展的可能性。
