Department of Stem Cell Biology, Konkuk University School of Medicine, Seoul, Republic of Korea; Center for Stem Cell Research, Institute of Advanced Biomedical Science, Konkuk University, Seoul, Republic of Korea.
Stem Cell Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, Republic of Korea.
Reprod Toxicol. 2018 Jun;78:169-177. doi: 10.1016/j.reprotox.2018.04.011. Epub 2018 Apr 22.
Animal models and human studies showed that in utero cigarette smoke exposure decreases sperm counts of offspring. This study used a mouse model to investigate the effects of maternal exposure to cigarette smoke on reproductive systems in F1 and F2 male offspring. Female ICR mice were exposed either to clean air or to cigarette smoke during pregnancy at the post-implantation stage. Epididymal sperm counts were decreased in a cigarette smoke dose-dependent manner in F1 (by 40-60%) and F2 males (by 23-40%) at postnatal day 56. In F1, the seminiferous epithelium heights were lower in the cigarette smoke-exposed groups than in the control group, and these effects were sustained in F2 males. Results suggest that maternal cigarette smoke exposure during pregnancy can have a multigenerational adverse effect on sperm counts in male offspring, which is mediated through in utero exposure of fetal germ cells to cigarette smoke.
动物模型和人体研究表明，子宫内吸烟会降低后代的精子数量。本研究使用小鼠模型来研究母体在妊娠后着床阶段暴露于香烟烟雾对 F1 和 F2 雄性后代生殖系统的影响。雌性 ICR 小鼠在怀孕期间要么暴露于清洁空气中，要么暴露于香烟烟雾中。在出生后第 56 天，F1（减少 40-60%）和 F2 雄性（减少 23-40%）的精子数量呈香烟烟雾剂量依赖性减少。在 F1 中，暴露于香烟烟雾的组的精小管上皮高度低于对照组，而在 F2 雄性中，这些影响持续存在。结果表明，母体在怀孕期间吸烟会对雄性后代的精子数量产生多代不良影响，这是通过胎儿生殖细胞在子宫内暴露于香烟烟雾来介导的。
