Cannarella Rossella, Condorelli Rosita A, Gusmano Carmelo, Barone Nunziata, Burrello Nunziatina, Aversa Antonio, Calogero Aldo E, La Vignera Sandro
Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Department of Experimental and Clinical Medicine, Magna Græcia University, 88100 Catanzaro, Italy.
J Clin Med. 2021 Mar 2;10(5):993. doi: 10.3390/jcm10050993.
To evaluate the changes of conventional sperm parameters in men who referred to an andrology reference center in Catania (Eastern Sicily, Italy) in the decade 2011-2020.
For this purpose, we selected-retrospectively and randomly-the reports of 1409 semen analyses performed according to the 2010 WHO criteria. Data on sperm concentration, total sperm count, progressive sperm motility, and percentage of normal forms were analyzed using linear regression of the raw and logarithmic-transformed data. The sperm parameters were subsequently pooled in two five-year periods (2011-2015 and 2016-2020) and compared with each other. Finally, the influence of the city of residence was assessed on five-year pooled data.
A slight but non-significant decline of total sperm count (-2.26 million/year; = 0.065) and the percentage of spermatozoa with normal morphology (-0.08%/year; = 0.057) was observed. In contrast, a significant increase of progressive sperm motility (+0.28%/year; = 0.008) over time was found. The total sperm count of the quinquennium 2016-2020 was significantly lower. and an upward trend of progressive sperm motility was found. compared to the years 2011-2015. No changes in sperm concentration and morphology occurred in the years 2011-2015 vs. 2016-2020. Sperm conventional parameters did not differ when the five-year pooled data were analyzed according to the town of residence.
Divergent trends of total sperm count and progressive sperm motility over time were found in patients from Eastern Sicily. This may point out the need of assessing whether a time-dependent change of biofunctional sperm parameters occurs to really understand the trend of sperm quality over time.
评估2011年至2020年期间前往卡塔尼亚（意大利西西里岛东部）男科参考中心就诊男性的常规精子参数变化。
为此，我们回顾性且随机选取了1409份根据2010年世界卫生组织标准进行的精液分析报告。使用原始数据和对数转换数据的线性回归分析精子浓度、总精子数、进行性精子活力和正常形态百分比的数据。随后将精子参数汇总为两个五年期（2011 - 2015年和2016 - 2020年）并相互比较。最后，根据居住城市评估对五年汇总数据的影响。
观察到总精子数略有但无显著下降（-226万/年；P = 0.065）以及正常形态精子百分比略有下降（-0.08%/年；P = 0.057）。相比之下，发现进行性精子活力随时间显著增加（+0.28%/年；P = 0.008）。2016 - 2020年这五年期的总精子数显著更低，并且发现进行性精子活力呈上升趋势，与2011 - 2015年相比。2011 - 2015年与2016 - 2020年期间精子浓度和形态无变化。根据居住城镇分析五年汇总数据时，精子常规参数无差异。
在西西里岛东部患者中发现总精子数和进行性精子活力随时间呈不同趋势。这可能表明需要评估生物功能精子参数是否随时间发生变化，以真正了解精子质量随时间的趋势。
