Ten Brinke M M, Boele H J, De Zeeuw C I
Department of Neuroscience, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands.
Department of Neuroscience, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands.
Neurosci Lett. 2019 Jan 1;688:26-36. doi: 10.1016/j.neulet.2018.04.035. Epub 2018 Apr 22.
The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. However, recent work highlights the addition of a conditioned Purkinje cell complex spike response, which at the level of the interposed nucleus seems to translate to a transient spike suppression that can be followed by a rapid spike facilitation. Here, we review the characteristics of these responses at the cerebellar cortical and nuclear level, and discuss possible origins and functions.
眨眼条件反射范式在一个已被深入理解的神经回路中捕捉到了关联学习的一种基本形式。小脑皮质浦肯野细胞简单锋电位抑制被广泛认为是条件反应（CRs）的主要潜在过程，导致支配下游眼睑肌肉的小脑核团中的神经元去抑制。然而，最近的研究突出了条件性浦肯野细胞复合锋电位反应的增加，在间位核水平上，这种反应似乎转化为短暂的锋电位抑制，随后可能会出现快速的锋电位易化。在这里，我们回顾了这些反应在小脑皮质和核水平的特征，并讨论了可能的起源和功能。
