Chen X Q, Zhang W, Li X Y
Department of Burns and Plastic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
Zhonghua Shao Shang Za Zhi. 2018 Apr 20;34(4):243-246. doi: 10.3760/cma.j.issn.1009-2587.2018.04.010.
Recently, researchers have focused on the micro-mechano-environment and the resulting mechanical cues which can regulate the morphology, structure, and function of cells. As a novel mechanotherapy, negative-pressure wound therapy (NPWT) has revolutionized the treatment of acute and chronic wounds. The effects of mechanics in use of NPWT has been noticed by researchers, and sporadic results have been reported, while the mechanisms of mechanosensitivity and mechanotransduction in affecting cell behaviors and promoting wound healing haven't been elucidated yet. In this article, we review the progress about the relevant mechanical forces of NPWT and the mechanical effects on major repairing cells involved in wound healing, in order to provide references for the better understanding of mechanobiology of NPWT to better wound healing.
最近，研究人员将重点放在了微观机械环境以及由此产生的能够调节细胞形态、结构和功能的机械信号上。作为一种新型的机械疗法，负压伤口治疗（NPWT）彻底改变了急慢性伤口的治疗方式。研究人员已经注意到NPWT应用中的力学效应，并报告了一些零星的结果，然而，影响细胞行为和促进伤口愈合的机械敏感性和机械转导机制尚未阐明。在本文中，我们综述了NPWT相关机械力的研究进展以及对伤口愈合中主要修复细胞的力学效应，以便为更好地理解NPWT的力学生物学从而促进伤口更好愈合提供参考。
