Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, 200433, China.
Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK.
Transl Psychiatry. 2018 Apr 25;8(1):90. doi: 10.1038/s41398-018-0139-1.
To analyze the functioning of the posterior cingulate cortex (PCC) in depression, we performed the first fully voxel-level resting state functional-connectivity neuroimaging analysis of depression of the PCC, with 336 patients with major depressive disorder and 350 controls. Voxels in the PCC had significantly increased functional connectivity with the lateral orbitofrontal cortex, a region implicated in non-reward and which is thereby implicated in depression. In patients receiving medication, the functional connectivity between the lateral orbitofrontal cortex and PCC was decreased back towards that in the controls. In the 350 controls, it was shown that the PCC has high functional connectivity with the parahippocampal regions which are involved in memory. The findings support the theory that the non-reward system in the lateral orbitofrontal cortex has increased effects on memory systems, which contribute to the rumination about sad memories and events in depression. These new findings provide evidence that a key target to ameliorate depression is the lateral orbitofrontal cortex.
为了分析抑郁患者后扣带皮层（PCC）的功能，我们对 PCC 的抑郁进行了首次全体素水平静息状态功能连接神经影像学分析，共纳入 336 名重度抑郁症患者和 350 名对照者。PCC 的体素与外侧眶额皮层（参与非奖赏的区域，与抑郁有关）的功能连接显著增加。在接受药物治疗的患者中，外侧眶额皮层与 PCC 之间的功能连接减少到接近对照组的水平。在 350 名对照者中，发现 PCC 与参与记忆的海马旁回区域具有高功能连接。这些发现支持了外侧眶额皮层中的非奖赏系统对记忆系统的影响增加，这有助于对抑郁中悲伤记忆和事件的反刍的理论。这些新发现提供了证据表明，改善抑郁的一个关键靶点是外侧眶额皮层。
