Ullrich S E, Magee M
Department of Immunology, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77030.
Transplantation. 1988 Jul;46(1):115-9. doi: 10.1097/00007890-198807000-00021.
Sensitization of UV-irradiated mice with alloantigen results in suppression of the immune response against that antigen. The induction of delayed hypersensitivity and the proliferative response of spleen cells isolated from the UV-irradiated mice are significantly suppressed. We demonstrate here that the rejection of tissue allografts is also suppressed after treatment of the recipient animals with UVR. Two signals, UVR and antigenic sensitization are required to suppress allograft rejection, exposure to UVR alone is not sufficient. The resulting immunosuppression is specific for the antigen used to sensitize the UV-irradiated animal. The induction of graft-versus-host disease was also significantly suppressed when spleen cells from UV-irradiated alloantigen sensitized mice were used to reconstitute lethally irradiated allogeneic mice. Our interpretation of these data is that the antigen-specific suppressor T cells present in the spleens of the UV-irradiated alloantigen sensitized mice are suppressing the immune response against the alloantigen. Thus, the induction of suppression by UVR serves as a novel method of suppressing graft rejection.
用同种异体抗原致敏紫外线照射的小鼠会导致针对该抗原的免疫反应受到抑制。从紫外线照射的小鼠中分离出的脾细胞的迟发型超敏反应诱导和增殖反应受到显著抑制。我们在此证明，在用紫外线辐射处理受体动物后，组织同种异体移植的排斥反应也受到抑制。抑制同种异体移植排斥反应需要两个信号，即紫外线辐射和抗原致敏，仅暴露于紫外线辐射是不够的。所产生的免疫抑制作用对用于致敏紫外线照射动物的抗原有特异性。当用来自紫外线照射的同种异体抗原致敏小鼠的脾细胞重建致死性照射的同种异体小鼠时，移植物抗宿主病的诱导也受到显著抑制。我们对这些数据的解释是，存在于紫外线照射的同种异体抗原致敏小鼠脾脏中的抗原特异性抑制性T细胞正在抑制针对同种异体抗原的免疫反应。因此，紫外线辐射诱导的抑制作用是一种抑制移植排斥反应的新方法。
