Ullrich S E
Transplantation. 1986 Sep;42(3):287-91. doi: 10.1097/00007890-198609000-00012.
Sensitization of C3H mice with allogeneic BALB/c spleen cells after a single exposure to ultraviolet (UV) radiation renders the mice incapable of generating an effective delayed-type hypersensitivity (DTH) response against BALB/c cells. In addition to the depressed DTH response, spleen cells from the UV-irradiated mice are unable to proliferate to alloantigen in a one-way mixed lymphocyte reaction (MLR). This inability to respond to alloantigen appears to be mediated by suppressor T cells, in that nylon-wool-nonadherent cells from the spleens of the UV-irradiated mice could suppress the MLR response of normal spleen cells to allogeneic spleen cells. In addition, the amount of interleukin-2 (IL-2) in the supernatants of the suppressed MLR cultures was also decreased. In all cases, the observed suppression was specific for the antigen used to sensitize the UV-irradiated animals. These data suggest that UV radiation can be used as an agent to induce a selective suppression of immune reactivity against allogeneic cells.
单次暴露于紫外线（UV）辐射后，用同种异体BALB/c脾细胞致敏C3H小鼠，会使这些小鼠无法对BALB/c细胞产生有效的迟发型超敏反应（DTH）。除了DTH反应受到抑制外，来自紫外线照射小鼠的脾细胞在单向混合淋巴细胞反应（MLR）中也无法对同种异体抗原增殖。这种对同种异体抗原无反应的能力似乎是由抑制性T细胞介导的，因为来自紫外线照射小鼠脾脏的尼龙毛非黏附细胞可以抑制正常脾细胞对同种异体脾细胞的MLR反应。此外，被抑制的MLR培养上清液中的白细胞介素-2（IL-2）含量也降低了。在所有情况下，观察到的抑制作用对用于致敏紫外线照射动物的抗原具有特异性。这些数据表明，紫外线辐射可作为一种诱导对同种异体细胞免疫反应选择性抑制的试剂。
