Maimónides Institute for Research in Biomedicine of Cordoba (IMIBIC), Avda. Menendez Pidal, s/n, 14004, Córdoba, Spain.
Rheumatology Department, Reina Sofia University Hospital, 14004, Córdoba, Spain.
Clin Rheumatol. 2018 Jun;37(6):1581-1588. doi: 10.1007/s10067-018-4112-4. Epub 2018 Apr 24.
To evaluate quality of life (QoL) in patients with axial spondyloarthritis (axSpA) and its association with disease activity, functionality, structural damage, and spinal mobility, using patient-reported outcomes. This was an observational, cross-sectional, and single-center study in which 100 consecutive patients with axSpA were included. We obtained from all patients' sociodemographic data and values related to disease activity, functionality, structural damage, mobility, and quality of life. The Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) was considered as the primary outcome. Pearson r statistic, Student's T test, and univariate and multivariate linear regressions were performed to relate ASQoL with the studied covariates. Mean ASQoL score in all patients was 4.02 ± 2.81, with statistically significant differences between male and female (3.61 ± 2.80 vs. 4.83 ± 2.70). Patients with high disease activity (measured by the ASAS-endorsed Disease Activity Score, ASDAS > 2.1) showed higher mean score in ASQoL than those with low disease activity (ASDAS ≤ 2.1) (3.21 ± 0.74 vs. 1.43 ± 0.43, p < 0.001). ASQoL presented a significant linear correlation with BASDAI, BASFI, and ASDAS (r > 0.60). However, disease duration was not significantly correlated with ASQoL. Finally, the 68.9% of the ASQoL variability (R = 0.689) was determined by BASDAI, BASFI, and mSASSS, presenting mSASSS a negative regression coefficient (- 0.035). In our study, the impairment of QoL was mainly associated with disease activity (BASDAI) and worsening of functionality (BASFI). However, there is an inverse relationship between the worsening of QoL and structural damage. In addition, disease duration does not seem to influence the patient's welfare.
评估轴性脊柱关节炎（axSpA）患者的生活质量（QoL）及其与疾病活动度、功能、结构损伤和脊柱活动度的关系，采用患者报告的结果。这是一项观察性、横断面和单中心研究，共纳入 100 例连续 axSpA 患者。我们从所有患者中获得了社会人口统计学数据以及与疾病活动度、功能、结构损伤、活动度和生活质量相关的值。使用强直性脊柱炎生活质量问卷（ASQoL）作为主要结果。进行了 Pearson r 统计、学生 t 检验以及单变量和多变量线性回归，以将 ASQoL 与研究协变量相关联。所有患者的平均 ASQoL 评分为 4.02±2.81，男性和女性之间存在统计学差异（3.61±2.80 与 4.83±2.70）。疾病活动度高（由 ASAS 认可的疾病活动评分，ASDAS>2.1 测量）的患者 ASQoL 评分高于疾病活动度低（ASDAS≤2.1）的患者（3.21±0.74 与 1.43±0.43，p<0.001）。ASQoL 与 BASDAI、BASFI 和 ASDAS 呈显著线性相关（r>0.60）。然而，疾病持续时间与 ASQoL 无显著相关性。最后，ASQoL 的 68.9%（R=0.689）由 BASDAI、BASFI 和 mSASSS 决定，mSASSS 的回归系数为负（-0.035）。在我们的研究中，生活质量的损害主要与疾病活动度（BASDAI）和功能恶化（BASFI）相关。然而，生活质量的恶化与结构损伤之间存在相反的关系。此外，疾病持续时间似乎不会影响患者的福利。
