McChesney D G, Boslego J W, Khan W N
Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
Antimicrob Agents Chemother. 1988 May;32(5):775-6. doi: 10.1128/AAC.32.5.775.
The MICs for 41 Neisseria gonorrhoeae strains from patients receiving spectinomycin treatment were determined by the agar dilution method and compared with the zones of inhibition produced by disks containing 100 micrograms of spectinomycin. Our data demonstrated a good correlation between the two methods. Moreover, a zone of inhibition of less than or equal to 15 mm was a good predictor of clinical treatment failures with spectinomycin.
采用琼脂稀释法测定了41株接受大观霉素治疗的淋病奈瑟菌的最低抑菌浓度(MIC),并与含100微克大观霉素的药敏纸片所产生的抑菌圈进行比较。我们的数据表明这两种方法具有良好的相关性。此外,抑菌圈小于或等于15毫米是大观霉素临床治疗失败的良好预测指标。