壮观霉素耐药淋病奈瑟菌
Spectinomycin resistant gonococci.
作者信息
Ison C A, Littleton K, Shannon K P, Easmon C S, Phillips I
出版信息
Br Med J (Clin Res Ed). 1983 Dec 17;287(6408):1827-9. doi: 10.1136/bmj.287.6408.1827.
Abstract
A study was conducted examining the properties of 10 clinical isolates of spectinomycin resistant gonococci from patients attending clinics at St Mary's and St Thomas's Hospitals, London. All of the isolates produced beta-lactamase and contained plasmids of 2.6, 4.4, and 24.5 megadaltons and required proline for growth. None produced aminoglycoside modifying enzymes. Resistance to spectinomycin was transferred from some of the isolates by transformation but at a much lower frequency than resistance to streptomycin. The isolates from St Mary's Hospital were detected after therapy with spectinomycin, whereas those from St Thomas's Hospital were not. Four recent non-beta-lactamase producing gonococci isolated at St Mary's Hospital and two isolated at St Thomas's Hospital also were not related to use of spectinomycin.
摘要
一项研究对从伦敦圣玛丽医院和圣托马斯医院诊所就诊患者中分离出的10株对壮观霉素耐药的淋球菌临床分离株的特性进行了检测。所有分离株均产生β-内酰胺酶，含有2.6、4.4和24.5兆道尔顿的质粒，生长需要脯氨酸。无一产生氨基糖苷修饰酶。壮观霉素耐药性可通过转化从部分分离株转移，但频率远低于链霉素耐药性。圣玛丽医院的分离株是在使用壮观霉素治疗后检测到的，而圣托马斯医院的分离株则不是。圣玛丽医院最近分离出的4株非β-内酰胺酶产生淋球菌和圣托马斯医院分离出的2株也与壮观霉素的使用无关。
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本文引用的文献
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