Oppenheim J J, Lew W, Akahoshi T, Matsushima K, Neta R
National Cancer Institute, Biological Response Modifiers Program, Frederick, MD.
Arzneimittelforschung. 1988 Mar;38(3A):461-5.
Interleukin 1 (IL 1) contributes to both acute and chronic inflammatory processes. Purified IL 1 by itself is only one of the signals that induces local inflammation. The contribution of IL 1 to local inflammatory reactions is influenced by exogenous stimuli, antagonists such as steroid hormones and TGF beta (tissue growth factor beta) and agonists such as TNF (tissue necrosis factor). IL 1 production is depressed by glucocorticoids, but glucocorticoids induce expression of receptors for IL 1 on selected cell types including B lymphocytes and fibroblasts. Thus, complex interactions between hormones and cytokines modulate immunological and inflammatory responses.
白细胞介素1（IL - 1）在急性和慢性炎症过程中均发挥作用。纯化后的IL - 1自身仅是诱导局部炎症的信号之一。IL - 1对局部炎症反应的作用受到外源性刺激、诸如类固醇激素和转化生长因子β（TGF - β，组织生长因子β）等拮抗剂以及诸如肿瘤坏死因子（TNF，组织坏死因子）等激动剂的影响。糖皮质激素可抑制IL - 1的产生，但糖皮质激素能诱导包括B淋巴细胞和成纤维细胞在内的特定细胞类型上IL - 1受体的表达。因此，激素与细胞因子之间复杂的相互作用调节着免疫和炎症反应。
