Hayashi Masafumi, Kawaguchi Takamasa, Durcova-Hills Gabriela, Imai Hiroshi
Laboratory of Reproductive Biology Graduate School of Agriculture Kyoto University Kyoto Japan.
The Fukui Research Institute Ono Pharmaceutical Companyy, Ltd. Fukui Japan.
Reprod Med Biol. 2017 Dec 10;17(2):107-114. doi: 10.1002/rmb2.12077. eCollection 2018 Apr.
The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC induction have been established in the mouse. Many attempts are reported to enhance our understanding of PGC development in other mammals, including human.
Here, original and review articles that have been published on PubMed are reviewed in order to give an overview of the literature that is focused on PGC development, including the specification of in vivo and in vitro in mice, human, porcine, and bovine.
Mammalian PGC development, in vivo and in vitro, have been studied primarily by using the mouse model as a template to study PGC specification in other mammals, including human, porcine, and bovine.
The growing body of published works reveals similarities, as well as differences, in PGC establishment in and between mouse and human.
生殖细胞谱系将遗传和表观遗传信息传递给下一代。原始生殖细胞（PGC）是精子或卵子的早期胚胎前体，已得到广泛研究。最近，在小鼠中建立了PGC诱导的体外模型。据报道，人们进行了许多尝试以增进我们对包括人类在内的其他哺乳动物中PGC发育的理解。
本文回顾了在PubMed上发表的原创文章和综述文章，以便对专注于PGC发育的文献进行概述，包括小鼠、人类、猪和牛体内和体外的特化过程。
哺乳动物PGC在体内和体外的发育主要是以小鼠模型为模板进行研究的，以探讨包括人类、猪和牛在内的其他哺乳动物中的PGC特化。
越来越多已发表的研究揭示了小鼠和人类体内及两者之间PGC建立过程中的异同。
