Unit of Cellular and Molecular Pathophysiology, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Front Immunol. 2018 Apr 10;9:769. doi: 10.3389/fimmu.2018.00769. eCollection 2018.
Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor. Since then, OPTN has been identified as a ubiquitin-binding protein involved in many signaling pathways and cellular processes, and mutations in the gene have been associated with glaucoma, Paget's disease of bone and neurodegenerative pathologies. Its role in autophagy, however, has attracted most attention in recent years and may explain (some of) the mechanisms behind the disease-associated mutations of OPTN. In this brief review, we focus on the role of OPTN in inflammation and immunity and describe how this may translate to its involvement in human disease.
Optineurin (OPTN) 是 20 年前在与一种已知抑制肿瘤坏死因子细胞溶解作用的病毒蛋白的酵母双杂交筛选中被发现的。从那时起，OPTN 已被确定为一种参与许多信号通路和细胞过程的泛素结合蛋白，并且该基因的突变与青光眼、骨 Paget 病和神经退行性病变有关。然而，它在自噬中的作用近年来引起了最多的关注，并且可能解释了 OPTN 相关疾病突变背后的部分机制。在这篇简短的综述中，我们重点介绍 OPTN 在炎症和免疫中的作用，并描述这如何转化为它在人类疾病中的参与。
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