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以及其他新兴成员的真正临床相关性是什么?

What is the true clinical relevance of and other emerging members?

作者信息

Vouga M, Kebbi-Beghdadi C, Liénard J, Baskin L, Baud D, Greub G

机构信息

Materno-fetal and Obstetrics Research Unit, Department "Femme-Mére-Enfant", University Hospital, Lausanne, Switzerland.

Center for Research on Intracellular Bacteria, Institute of Microbiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.

出版信息

New Microbes New Infect. 2018 Jan 31;23:1-5. doi: 10.1016/j.nmni.2018.01.001. eCollection 2018 May.

Abstract

and are emerging related bacteria. Similar to the pathogenic organisms and these emerging bacteria are implicated in human genital infections and respiratory diseases. We used a screening strategy based on a newly developed -specific quantitative real-time PCR (qPCR) and a pan- qPCR. We could not detect in 458 respiratory, genitourinary, cardiac and hepatic samples tested. One urethral swab was positive for We observed a low prevalence of in respiratory samples (1/200, 0.5%), which suggests that is an uncommon respiratory pathogen. Furthermore, we screened 414 human serum samples from Switzerland, England and Israel and observed a low prevalence (<1%) of exposure to Conversely, humans were commonly exposed to with seroprevalences ranging from 8.6% to 32.5%. is not a clinically relevant pathogen, but further research investigating the role of is needed.

摘要

[细菌名称1]和[细菌名称2]是新出现的相关细菌。与致病生物[其他细菌名称1]和[其他细菌名称2]类似,这些新出现的细菌与人类生殖器感染和呼吸道疾病有关。我们使用了一种基于新开发的[细菌名称1]特异性定量实时PCR(qPCR)和泛[细菌名称2] qPCR的筛查策略。在检测的458份呼吸道、泌尿生殖系统、心脏和肝脏样本中未检测到[细菌名称1]。一份尿道拭子检测出[细菌名称2]呈阳性。我们观察到[细菌名称1]在呼吸道样本中的流行率较低(1/200,0.5%),这表明[细菌名称1]是一种不常见的呼吸道病原体。此外,我们对来自瑞士、英国和以色列的414份人类血清样本进行了筛查,发现接触[细菌名称1]的流行率较低(<1%)。相反,人类普遍接触[细菌名称2],血清阳性率在8.6%至32.5%之间。[细菌名称1]不是临床相关病原体,但需要进一步研究以调查[细菌名称1]的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dab9/5913364/a97b597bc9be/figs1.jpg

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