Mandecki Wlodek, Qian Jay, Gedzberg Katie, Gruda Maryanne, Rodriguez Efrain Frank, Nesbitt Leslie, Riben Michael
PharmaSeq, Inc., Westampton, NJ, USA.
Cytosorbents Corporation, Monmouth Junction, Westampton, NJ, USA.
J Pathol Inform. 2018 Apr 2;9:9. doi: 10.4103/jpi.jpi_64_17. eCollection 2018.
The tagging system is based on a small, electronic, wireless, laser-light-activated microtransponder named "p-Chip." The p-Chip is a silicon integrated circuit, the size of which is 600 μm × 600 μm × 100 μm. Each p-Chip contains a unique identification code stored within its electronic memory that can be retrieved with a custom reader. These features allow the p-Chip to be used as an unobtrusive and scarcely noticeable ID tag on glass slides and tissue cassettes.
The system is comprised of p-Chip-tagged sample carriers, a dedicated benchtop p-Chip ID reader that can accommodate both objects, and an additional reader (the Wand), with an adapter for reading IDs of glass slides stored vertically in drawers. On slides, p-Chips are attached with adhesive to the center of the short edge, and on cassettes - embedded directly into the plastic. ID readout is performed by bringing the reader to the proximity of the chip. Standard histopathology laboratory protocols were used for testing.
Very good ID reading efficiency was observed for both glass slides and cassettes. When processed slides are stored in vertical filing drawers, p-Chips remain readable without the need to remove them from the storage location, thereby improving the speed of searches in collections. On the cassettes, the ID continues to be readable through a thin layer of paraffin. Both slides and tissue cassettes can be read with the same reader, reducing the need for redundant equipment.
The p-Chip is stable to all chemical challenges commonly used in the histopathology laboratory, tolerates temperature extremes, and remains durable in long-term storage. The technology is compatible with laboratory information management systems software systems. The p-Chip system is very well suited for identification of glass slides and cassettes in the histopathology laboratory.
标记系统基于一种名为“p芯片”的小型、电子、无线、激光激活微转发器。p芯片是一种硅集成电路，尺寸为600μm×600μm×100μm。每个p芯片在其电子存储器中存储有唯一的识别码，可通过定制读取器检索。这些特性使p芯片能够用作载玻片和组织盒上不显眼且几乎难以察觉的身份标签。
该系统由带有p芯片的样本载体、可容纳这两种物品的专用台式p芯片身份读取器以及一个额外的读取器（手持读取器）组成，手持读取器带有一个适配器，用于读取垂直存放在抽屉中的载玻片的身份信息。在载玻片上，p芯片用粘合剂附着在短边的中心，在组织盒上则直接嵌入塑料中。通过将读取器靠近芯片进行身份识别读取。使用标准组织病理学实验室方案进行测试。
载玻片和组织盒均观察到非常好的身份识别读取效率。当处理后的载玻片垂直存放在档案抽屉中时，无需从存放位置取出p芯片即可继续读取，从而提高了藏品搜索速度。在组织盒上，通过一薄层石蜡仍可继续读取身份信息。载玻片和组织盒均可使用同一读取器读取，减少了对冗余设备的需求。
p芯片对组织病理学实验室常用的所有化学挑战均稳定，耐受极端温度，且在长期储存中仍耐用。该技术与实验室信息管理系统软件系统兼容。p芯片系统非常适合在组织病理学实验室中对载玻片和组织盒进行识别。
