Khodaverdi Elham, Ahmadi Mina, Kamali Hossein, Hadizadeh Farzin
Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.
Int J Pharm Investig. 2017 Oct-Dec;7(4):174-181. doi: 10.4103/jphi.JPHI_77_17.
Synthetic Mobil Crystalline Material 41 (MCM-41) as a mesoporous material and functionalized MCM-41 using aminopropyl groups were studied in order to investigate their ability to encapsulate and to control the release of diclofenac sodium and piroxicam.
MCM-41 was synthesized through sol-gel procedure and functionalized with aminopropyl groups. The physicochemical properties of MCM-41 were studied through particle size analysis, infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and carbon-hydrogen-nitrogen analysis. Diclofenac sodium and piroxicam were loaded into the MCM-41 matrix using the filtration and solvent evaporation methods. The drug-loading capacity was determined by ultraviolet, Fourier transform infrared, X-ray diffraction, and Brunauer-Emmett-Teller analysis.
According to the results for pure drug release, >57% was released in the 1 h, but when these drugs were loaded into pure Mobil Crystalline Material 41 (MCM-41) and functionalized MCM-41, the release into the simulated gastrointestinal medium was less, continuous, and slower. The release of piroxicam from functionalized MCM-41 was slower than that from MCM-41 in the simulated intestinal medium because of the formation of electrostatic bonds between piroxicam and the aminopropyl groups of the functionalized MCM-41. However, in the case of diclofenac sodium, there was no significant difference between pure MCM-41 and functionalized MCM-41. The difference between piroxicam and diclofenac sodium was due to the high solubility of diclofenac sodium in the intestinal medium (pH 6.8), which caused more rapid release from the matrixes than for piroxicam.
Our findings indicate that, after functionalization of MCM-41, it could offer a good means of delivering controlled diclofenac sodium and piroxicam.
研究合成介孔材料 Mobil 结晶材料 41（MCM - 41）以及用氨丙基官能化的 MCM - 41，以考察它们对双氯芬酸钠和吡罗昔康的包封能力及控释能力。
通过溶胶 - 凝胶法合成 MCM - 41 并用氨丙基进行官能化。通过粒度分析、红外光谱、扫描电子显微镜、透射电子显微镜以及碳 - 氢 - 氮分析对 MCM - 41 的物理化学性质进行研究。采用过滤和溶剂蒸发法将双氯芬酸钠和吡罗昔康载入 MCM - 41 基质中。通过紫外、傅里叶变换红外、X 射线衍射和布鲁诺尔 - 埃米特 - 泰勒分析测定载药量。
根据纯药物释放结果，1 小时内释放量>57%，但当这些药物载入纯 Mobil 结晶材料 41（MCM - 41）和官能化的 MCM - 41 时，在模拟胃肠道介质中的释放较少、持续且较慢。在模拟肠道介质中，由于吡罗昔康与官能化 MCM - 41 的氨丙基之间形成静电键，吡罗昔康从官能化 MCM - 41 中的释放比从 MCM - 41 中的释放更慢。然而，对于双氯芬酸钠，纯 MCM - 41 和官能化 MCM - 41 之间没有显著差异。吡罗昔康和双氯芬酸钠之间的差异是由于双氯芬酸钠在肠道介质（pH 6.8）中的高溶解度，这导致其从基质中的释放比吡罗昔康更快。
我们的研究结果表明，MCM - 41 官能化后可成为递送双氯芬酸钠和吡罗昔康的良好控释手段。
