Jones D B, Howden C W, Burget D W, Silletti C, Hunt R H
Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Gut. 1988 Jul;29(7):890-3. doi: 10.1136/gut.29.7.890.
The effects of a specific H2 receptor agonist impromidine, on gastric acid secretion were measured in six patients with duodenal ulcer in clinical remission before and after three months treatment with ranitidine 150 mg nocte. After treatment basal acid output increased from 1.2 to 2.8 mmol/h and after maximal impromidine stimulation from 36.9 (4.7) to 44.2 (6.2) mmol/h (p less than 0.02). Intravenous ranitidine 50 mg was given at the end of the impromidine infusion on each study day; the antisecretory effect of intravenous ranitidine was accentuated after the treatment with ranitidine from a trough acid output of 8.5 (1.2) mmol/h before, to 3.8 (1.5) mmol/h (p less than 0.05) after, treatment. The increased response to the H2 agonist impromidine and the H2 antagonist ranitidine after treatment with ranitidine suggests an enhanced sensitivity of the H2 receptor. This might be explained on the basis of an increase in the number of H2 receptors ('up-regulation').
在6例处于临床缓解期的十二指肠溃疡患者中，测量了特异性H2受体激动剂英普咪定对胃酸分泌的影响，这些患者在接受雷尼替丁150mg每晚一次治疗3个月之前和之后进行了测量。治疗后基础酸排量从1.2mmol/h增加至2.8mmol/h，英普咪定最大刺激后从36.9（4.7）mmol/h增至44.2（6.2）mmol/h（p<0.02）。在每个研究日，英普咪定输注结束时静脉给予雷尼替丁50mg；雷尼替丁治疗后，静脉注射雷尼替丁的抑酸作用增强，基础酸排量从治疗前的8.5（1.2）mmol/h降至治疗后的3.8（1.5）mmol/h（p<0.05）。雷尼替丁治疗后对H2激动剂英普咪定和H2拮抗剂雷尼替丁的反应增强，提示H2受体敏感性增强。这可能是基于H2受体数量增加（“上调”）来解释的。
