Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Acta Paediatr. 2018 Nov;107(11):1953-1965. doi: 10.1111/apa.14369. Epub 2018 May 21.
Previous studies have found high rates of stunted linear growth in Greenlandic children. We measured growth patterns in Greenland and compared them with international growth charts.
The study cohort comprised 279 healthy children aged 6-10 years in 2012. They participated in two pregnancy and birth cohorts in Greenland and longitudinal growth data as birth was extracted from their medical records. Growth reference ranges were estimated with the lambda-mu-sigma (LMS) method and compared with growth charts from Denmark and the World Health Organization (WHO).
The children's mean length, weight and head circumference were significantly larger than the WHO growth charts (p < 0.001). We found that 21-28% of the children aged zero to one years exceeded the WHO growth chart for length by more than two standard deviations. For weight and head circumference, 9-16% of the children aged 0-10 years and 9-11% of the children from zero to two years exceeded the WHO charts by more than two standard deviations. The Danish references were exceeded to a lesser degree.
This study showed that the growth of Greenlandic children up to 10 years was no longer stunted. Major determining factors suggested are genetic admixture, maternal overweight, changes in nutrition and improved health.
先前的研究发现格陵兰儿童线性生长迟缓的发生率很高。我们测量了格陵兰的生长模式，并将其与国际生长图表进行了比较。
研究队列包括 2012 年 6-10 岁的 279 名健康儿童。他们参加了格陵兰的两项妊娠和出生队列研究，其纵向生长数据从他们的病历中提取。使用 lambda-mu-sigma（LMS）方法估计生长参考范围，并将其与丹麦和世界卫生组织（WHO）的生长图表进行比较。
儿童的平均身高、体重和头围明显大于 WHO 生长图表（p<0.001）。我们发现，0-1 岁的儿童中有 21-28%的身高超过 WHO 生长图表的两个标准差。对于体重和头围，0-10 岁的儿童中有 9-16%，0-2 岁的儿童中有 9-11%，超过了 WHO 图表的两个标准差。丹麦的参考值超出程度较小。
本研究表明，10 岁以下格陵兰儿童的生长不再受到限制。主要的决定因素是遗传混合、母亲超重、营养变化和健康状况改善。
