Christova Peka, Georgopoulos Apostolos P
Department of Neuroscience, University of Minnesota Medical School , Minneapolis, Minnesota.
Brain Sciences Center, Minneapolis Department of Veterans Affairs Health Care System , Minneapolis, Minnesota.
J Neurophysiol. 2018 Aug 1;120(2):760-764. doi: 10.1152/jn.00137.2018. Epub 2018 Apr 25.
Neural interactions in local cortical networks critically depend on the distance between interacting elements: the shorter the distance, the stronger the interactions. Here we quantified these interactions in six cortical areas of 854 individuals, including monozygotic and dizygotic twins, nontwin siblings, and nonrelated individuals. We found that the strength of zero-lag correlation between prewhitened, resting-state, blood level oxygenation-dependent functional magnetic resonance imaging time series decreased with distance as a power law. The rate of decrease, b, varied among individuals by ~1.9×, was highly correlated between hemispheres, but differed among areas (by ~1.2×) in a systematic fashion, becoming progressively less steep from frontal to occipital areas. With respect to twin status, b was significantly correlated between monozygotic twins, less so between dizygotic twins or nontwin siblings, and not at all in nonrelated individuals. These results quantify the lawful, distance-related cortical interactions and demonstrate, for the first time, the heritability of their power law. NEW & NOTEWORTHY Local cortical circuitry involves orderly neuronal interactions. A key feature of these interactions is that they are stronger the closer the interacting neurons. Here we quantified this crucial dependence of neural interactions on distance with functional magnetic resonance imaging and found that the strength of interactions decreases with distance as a power law that is very similar in all cortical lobes and heritable. These findings identify an invariant and heritable property of local cortical organization.
距离越短，相互作用越强。在这里，我们对854名个体的六个皮质区域中的这些相互作用进行了量化，这些个体包括同卵双胞胎、异卵双胞胎、非双胞胎兄弟姐妹以及无血缘关系的个体。我们发现，经预白化处理的静息态血氧水平依赖性功能磁共振成像时间序列之间的零滞后相关性强度随距离呈幂律下降。下降速率b在个体间变化约1.9倍，在半球间高度相关，但在不同区域间（约1.2倍）呈系统性差异，从额叶到枕叶区域逐渐变缓。关于双胞胎状态，b在同卵双胞胎之间显著相关，在异卵双胞胎或非双胞胎兄弟姐妹之间相关性较低，在无血缘关系的个体中则完全不相关。这些结果量化了符合规律的、与距离相关的皮质相互作用，并首次证明了其幂律的遗传性。新发现与值得关注之处 局部皮质回路涉及有序的神经元相互作用。这些相互作用的一个关键特征是，相互作用的神经元越靠近，它们之间的相互作用就越强。在这里，我们用功能磁共振成像量化了神经相互作用对距离的这种关键依赖性，发现相互作用强度随距离呈幂律下降，这在所有皮质叶中非常相似且具有遗传性。这些发现确定了局部皮质组织的一种不变且可遗传的特性。
