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生长迟缓发生的时间对营养结局潜在决定因素的观察性分析具有重要意义。

The timing of growth faltering has important implications for observational analyses of the underlying determinants of nutrition outcomes.

机构信息

International Food Policy Research Institute, Washington, District of Columbia, United States of America.

出版信息

PLoS One. 2018 Apr 25;13(4):e0195904. doi: 10.1371/journal.pone.0195904. eCollection 2018.

Abstract

BACKGROUND

Growth faltering largely occurs in the first 23 months after birth and is thought to be largely determined by various harmful or protective socioeconomic conditions. Children 23 months or younger, however, have only been partially exposed to these conditions, implying that statistical associations between these conditions and child growth may be substantially smaller in samples that include younger children.

OBJECTIVES

To test the prediction that associations between child anthropometric outcomes and various socioeconomic conditions are systematically different for older and younger children.

METHODS

We analyzed data for 699,421 children aged 0-59 months, drawn from 125 DHS implemented between 1992 and 2014 in 57 countries. The outcome variables were height-for-age Z scores (HAZ) and stunting (HAZ<-2), and weight-for-height z scores (WHZ) and wasting (WHZ<-2). Independent variables included household wealth, parental education, maternal height, demographic factors, and exposure to WASH and health services. We used age-disaggregated regressions to examine how the associations between dependent and independent variables vary across different child age ranges.

RESULTS

Non-parametric regression results reaffirmed that most linear growth faltering and wasting takes place prior to 23 months of age. Estimates of the magnitude of association with wealth, education and improved toilet use from HAZ regressions are systematically larger in the sample of children 24-59 months than in the 0-23 month or 0-59 month samples; the reverse is true for WHZ regressions.

CONCLUSIONS

Previous observational analyses appear to substantially underestimate the protective impacts of a wide range of underlying determinants on stunting. Conversely, wasting rates are typically low for children 24-59 months, implying that associations between underlying conditions and wasting may be stronger for children 0-23 months of age. Such analyses should pay closer attention to age disaggregation; researchers should be aware of the age effect reported in the current study and present analysis stratified by age.

摘要

背景

生长迟缓主要发生在出生后 23 个月内,据认为主要由各种有害或保护的社会经济条件决定。然而,23 个月或以下的儿童仅部分接触到这些条件,这意味着在包括年龄较小儿童的样本中,这些条件与儿童生长之间的统计关联可能要小得多。

目的

检验以下预测:儿童体格测量结果与各种社会经济条件之间的关联,在年龄较大和较小的儿童中存在系统差异。

方法

我们分析了来自 1992 年至 2014 年间在 57 个国家实施的 125 项 DHS 中,699,421 名 0-59 月龄儿童的数据。因变量为身高别年龄 Z 评分(HAZ)和发育迟缓(HAZ<-2),体重别身高 Z 评分(WHZ)和消瘦(WHZ<-2)。自变量包括家庭财富、父母教育、母亲身高、人口因素以及接触 WASH 和卫生服务。我们使用年龄分解回归来检验依赖变量和独立变量之间的关联如何在不同的儿童年龄范围内发生变化。

结果

非参数回归结果再次证实,大多数线性生长迟缓和消瘦发生在 23 个月之前。从 HAZ 回归估计的与财富、教育和改善厕所使用的关联程度,在 24-59 月龄儿童样本中系统地大于 0-23 月龄或 0-59 月龄样本;WHZ 回归则相反。

结论

以前的观察性分析似乎大大低估了广泛的潜在决定因素对发育迟缓的保护作用。相反,24-59 月龄儿童的消瘦率通常较低,这意味着潜在条件与消瘦之间的关联对于 0-23 月龄儿童可能更强。这种分析应更加关注年龄分解;研究人员应注意本研究和当前分析中报告的年龄效应,并按年龄分层呈现分析结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1cc/5919068/9cbdc70e1d99/pone.0195904.g001.jpg

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