Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore.
Department of Medicine, National University Health System, Singapore, Republic of Singapore.
PLoS One. 2018 Apr 25;13(4):e0196328. doi: 10.1371/journal.pone.0196328. eCollection 2018.
Body fatness is associated with risk of coronary heart disease and it has been postulated that epicardial adipose tissue (EAT) may have a particularly detrimental effect because of its localized toxic effects. We therefore aimed to examine the association between EAT and coronary artery calcification and compared this with associations for visceral adipose tissue (VAT) and other regional fat depots.
We conducted a cross-sectional study of 487 Chinese participants aged 50 years old and above, living in Singapore. Participants, free from known diabetes mellitus and coronary heart diseases, completed interviews, a health screening to evaluate obesity and cardiovascular disease risk factors, and computed tomography scans of the abdomen and coronary arteries. Associations between regional fat depots and subclinical atherosclerosis defined as CAC> = 100 were determined by multiple logistic regression analysis.
Epicardial adipose tissue (EAT) was highly correlated with visceral adipose tissue (VAT) (Pearson r = 0.72) and trunk fat mass (r = 0.66). The age and sex-adjusted odd ratio (OR) (in 1-SD increase) of subclinical atherosclerosis was 1.28 (1.01-1.61) for EAT and 1.40 (1.04-1.88) for VAT. These associations were weaker and non-significant after adjusting for markers of dyslipidemia and hyperglycemia. Total body fat, subcutaneous abdominal fat, and leg, arm and trunk fat mass were not significantly associated with atherosclerosis.
VAT and EAT showed similar associations with coronary artery calcification and the associations could be mediated by traditional risk factors in this ethnic Chinese population.
体脂肪与冠心病风险相关，有人推测心外膜脂肪组织（EAT）可能具有特别有害的影响，因为它具有局部毒性作用。因此，我们旨在研究 EAT 与冠状动脉钙化之间的关系，并将其与内脏脂肪组织（VAT）和其他局部脂肪沉积的关系进行比较。
我们对居住在新加坡的 487 名 50 岁及以上的中国参与者进行了横断面研究。参与者无已知的糖尿病和冠心病，完成了访谈、健康筛查以评估肥胖和心血管疾病的危险因素，并对腹部和冠状动脉进行了计算机断层扫描。使用多因素逻辑回归分析确定局部脂肪沉积与亚临床动脉粥样硬化（定义为 CAC>=100）之间的关系。
心外膜脂肪组织（EAT）与内脏脂肪组织（VAT）（皮尔逊 r = 0.72）和躯干脂肪质量（r = 0.66）高度相关。调整年龄和性别后，亚临床动脉粥样硬化的比值比（OR）（在 1-SD 增加）为 EAT 为 1.28（1.01-1.61），VAT 为 1.40（1.04-1.88）。调整血脂异常和高血糖标志物后，这些关联较弱且无统计学意义。全身脂肪、腹部皮下脂肪以及腿部、手臂和躯干脂肪质量与动脉粥样硬化无显著相关性。
VAT 和 EAT 与冠状动脉钙化具有相似的相关性，在这个华裔人群中，这些相关性可能由传统的危险因素介导。
