Curra Marina, Soares Junior Luiz Alberto Valente, Martins Manoela Domingues, Santos Paulo Sérgio da Silva
Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil.
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2018;16(1):eRW4007. doi: 10.1590/s1679-45082018rw4007. Epub 2018 Apr 23.
This review aimed to analyze the scientific production on severity of oral mucositis as an adverse effect of chemotherapy. To this end, we performed a search at PubMed databases combining the keywords "oral mucositis" and "chemotherapy protocol". To describe the investigation, the following variables were considered: journal, year/place, study design, sample, protocol used and incidence of oral mucositis. A total of 547 articles were retrieved, of which 26 were selected. Out of these 26, only 2 reported severity of oral mucositis; the others only reported the presence of the condition. Protocols for treating different types of carcinoma were evaluated in 16 (61.53%) studies, for hematological malignancies in 6 (23.07%), and for hematopoietic stem cell transplantation in 4 (15.4%). Protocols for hematopoietic stem cell transplantation entail a high risk for oral mucositis, just as chemotherapy with cytarabine and high-dose 5-fluorouracil, alkylating agents and platinumbased compounds. To provide the best prevention and treatment for oral mucositis, it is essential to know the chemotherapy protocols used and their effects on the oral cavity.
本综述旨在分析作为化疗不良反应的口腔黏膜炎严重程度的科研成果。为此，我们在PubMed数据库中进行了检索，将关键词“口腔黏膜炎”和“化疗方案”相结合。为描述该调查，考虑了以下变量：期刊、年份/地点、研究设计、样本、所用方案以及口腔黏膜炎的发生率。共检索到547篇文章，其中26篇被选中。在这26篇中，只有2篇报告了口腔黏膜炎的严重程度；其他文章仅报告了该病的存在情况。16项（61.53%）研究评估了治疗不同类型癌症的方案，6项（23.07%）研究评估了血液系统恶性肿瘤的方案，4项（15.4%）研究评估了造血干细胞移植的方案。造血干细胞移植方案导致口腔黏膜炎的风险很高，阿糖胞苷和高剂量5-氟尿嘧啶化疗、烷化剂和铂类化合物化疗也是如此。为了为口腔黏膜炎提供最佳的预防和治疗，了解所用的化疗方案及其对口腔的影响至关重要。
