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新生儿败血症的新诊断可能性

New Diagnostic Possibilities for Neonatal Sepsis.

作者信息

Tzialla Chryssoula, Manzoni Paolo, Achille Cristian, Bollani Lina, Stronati Mauro, Borghesi Alessandro

机构信息

Neonatology and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico "San Matteo," Pavia, Italy.

Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy.

出版信息

Am J Perinatol. 2018 May;35(6):575-577. doi: 10.1055/s-0038-1639361. Epub 2018 Apr 25.

Abstract

Progress in neonatal care has decrease morbidity and mortality due to neonatal sepsis (NS). Although diagnosis of sepsis continues to rely on blood culture, this method is too slow and limited by false-negative results. There are numerous sepsis biomarkers that have been evaluated for the early diagnosis of NS, but, to date, there is no single ideal biomarker, though novel biomarkers are becoming more sophisticated and specific in their clinical applications. This review provides an overview of the current diagnostic approaches available or under development for diagnosing NS.

摘要

新生儿护理方面的进展降低了新生儿败血症(NS)导致的发病率和死亡率。尽管败血症的诊断仍依赖血培养,但这种方法过于缓慢且受假阴性结果限制。已有众多败血症生物标志物用于NS的早期诊断评估,但迄今为止,尚无单一理想的生物标志物,不过新型生物标志物在临床应用中正变得越来越精密和特异。本文综述了目前可用于或正在研发的NS诊断方法。

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