Lee Jung-Ah, Hwang Min-A, Han Jang-Hyuck, Cho Eun-Haeng, Lee Joong-Bok, Park Seung-Yong, Song Chang-Seon, Choi In-Soo, Lee Sang-Won
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea; Division of Emerging Infectious Disease and Vector Research, National Institute of Health, Centers for Disease Control and Prevention, Osong-eup, CheongJu, Chungcheongbuk-do 363-951, Republic of Korea.
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
Vet Immunol Immunopathol. 2018 Feb;196:14-17. doi: 10.1016/j.vetimm.2017.12.001. Epub 2017 Dec 5.
Porcine mycoplasmal pneumonia is a significant disease problem in the swine industry. The causative agents include Mycoplasma hyopneumoniae and Mycoplasma hyorhinis. M. hyopneumoniae is the major pathogen contributing to the porcine respiratory disease complex, but is difficult to isolate from the respiratory tract and tonsils, whereas M. hyorhinis is not. Although M. hyorhinis is commonly detected in the lungs, the role of M. hyorhinis as a cause of pneumonia remains unclear. Current vaccines for porcine mycoplasmal pneumonia only include M. hyopneumoniae, not M. hyorhinis. M. hyopneumoniae vaccines are widely used, but disease still occurs because of poor vaccine efficacy and possibly the presence of M. hyorhinis. In this study, an inactivated vaccine containing a mixture of M. hyorhinis and M. hyopneumoniae was generated and evaluated for safety, immunogenicity, and protective efficacy against challenge with M. hyorhinis in pigs. The inactivated vaccine induced an antibody response and reduced pneumonic lesions in the lungs and tracheas compared with the non-vaccinated group.
猪支原体肺炎是养猪业中一个重要的疾病问题。病原体包括猪肺炎支原体和猪鼻支原体。猪肺炎支原体是导致猪呼吸道疾病综合征的主要病原体，但很难从呼吸道和扁桃体中分离出来，而猪鼻支原体则不然。虽然猪鼻支原体在肺部很常见，但它作为肺炎病因的作用仍不清楚。目前用于猪支原体肺炎的疫苗仅包括猪肺炎支原体，不包括猪鼻支原体。猪肺炎支原体疫苗被广泛使用，但由于疫苗效果不佳以及可能存在猪鼻支原体，疾病仍然会发生。在本研究中，制备了一种含有猪鼻支原体和猪肺炎支原体混合物的灭活疫苗，并对其安全性、免疫原性以及对猪感染猪鼻支原体的攻毒保护效力进行了评估。与未接种疫苗的组相比，该灭活疫苗诱导了抗体反应，并减少了肺部和气管中的肺炎病变。
