通过硅-硼键活化原位生成硅锌试剂实现端基炔烃的硅锌化和硅硼化反应
In Situ Generation of Silylzinc by Si-B Bond Activation Enabling Silylzincation and Silaboration of Terminal Alkynes.
作者信息
Nagashima Yuki, Yukimori Daiki, Wang Chao, Uchiyama Masanobu
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Cluster of Pioneering Research (CPR), Advanced Elements Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
出版信息
Angew Chem Int Ed Engl. 2018 Jul 2;57(27):8053-8057. doi: 10.1002/anie.201802887. Epub 2018 May 30.
A new protocol has been designed for the in situ generation of unstable Si-Zn species through the reaction of dialkylzinc, phosphine, and silylborane (Si-B). Successive reactions with various terminal alkynes using this protocol enabled highly controllable regio-/stereo-/chemoselective silylzincation and silaboration on demand without the need for a transition-metal catalyst.
一种新的方案已被设计出来，用于通过二烷基锌、膦和硅硼烷（Si-B）的反应原位生成不稳定的硅锌物种。使用该方案与各种末端炔烃连续反应，无需过渡金属催化剂，即可按需实现高度可控的区域/立体/化学选择性硅锌化和硅硼化。
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