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一种基于催化发夹组装的靶响应脂质体,可实现对与结核病相关细胞因子的高灵敏度检测。

A target-responsive liposome activated by catalytic hairpin assembly enables highly sensitive detection of tuberculosis-related cytokine.

机构信息

Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

出版信息

Chem Commun (Camb). 2018 May 8;54(38):4870-4873. doi: 10.1039/c8cc01542b.

DOI:10.1039/c8cc01542b
PMID:29697111
Abstract

Here, we propose a new fluorescence method to detect tuberculosis-related cytokine by using a target-responsive liposome activated by catalytic hairpin assembly. The method combines a DNA self-assembly based amplification process with a liposome-based signal amplification process, therefore offering a very high sensitivity.

摘要

在这里,我们提出了一种新的荧光法,通过使用催化发夹组装激活的靶标响应脂质体来检测与结核病相关的细胞因子。该方法结合了基于 DNA 自组装的扩增过程和基于脂质体的信号扩增过程,因此具有非常高的灵敏度。

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引用本文的文献

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Cytokines: From Clinical Significance to Quantification.细胞因子:从临床意义到定量分析。
Adv Sci (Weinh). 2021 Aug;8(15):e2004433. doi: 10.1002/advs.202004433. Epub 2021 Jun 10.