Institut Européen des Membranes, UMR5635, Université de Montpellier CNRS ENSCM, Place Eugène Bataillon, 34090 Montpellier, France.
Phys Chem Chem Phys. 2018 May 9;20(18):12799-12807. doi: 10.1039/c8cp01787e.
Solid-state nanopore technology for nanoparticle sensing is considered for the development of analytical tools to characterise their size, shape or zeta potential. In this field, it is crucial to understand how the nanopore inner surface influences the dynamic of nanoparticle translocation. Here, three single nanopores directly drilled in metal alloys (titanium nitride, titanium-tantalum and tantalum) are considered. The translocation of polystyrene nanoparticles coated with ssDNA is investigated by the resistive pulse method at different concentrations and voltages. The results show that the nanoparticle energy barrier for entrance into the pore decreases for nanopores that exhibits a higher surface energy and hydrophilicity, while the dwell time is found to depend on the nanopore surface state. Overall, this study demonstrates that the control of nanopore surface state must be taken into account for the resistive pulse experiments for nanoparticle detection.
用于纳米粒子传感的固态纳米孔技术被认为是开发分析工具的基础，这些工具可用于表征纳米粒子的大小、形状或 Zeta 电位。在这个领域，了解纳米孔内表面如何影响纳米粒子迁移的动力学至关重要。在这里，研究了三种直接在金属合金（氮化钛、钛钽和钽）中钻制的单纳米孔。通过电阻脉冲法在不同浓度和电压下研究了 ssDNA 包覆的聚苯乙烯纳米粒子的迁移。结果表明，对于表面能和润湿性较高的纳米孔，纳米粒子进入孔的能量势垒降低，而停留时间则取决于纳米孔的表面状态。总的来说，这项研究表明，在用于纳米粒子检测的电阻脉冲实验中，必须考虑纳米孔表面状态的控制。
