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在没有使用抗菌药物的情况下获得耐多药生物体。

Acquisition of Multidrug-resistant Organisms in the Absence of Antimicrobials.

机构信息

Division of Infectious Diseases, Brown University, Providence, Rhode Island.

Cornerstone Research Group, Burlington, Ontario, Canada.

出版信息

Clin Infect Dis. 2018 Oct 15;67(9):1437-1440. doi: 10.1093/cid/ciy358.

DOI:10.1093/cid/ciy358
PMID:29697767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6186851/
Abstract

A nested case-control study among 137 nursing home residents who did not receive antimicrobials, of whom 44 acquired a multidrug-resistant organism, was performed. Risk factors for acquisition included gastrointestinal medications that affect the gut microbiome, number of visits from healthcare workers, pressure ulcers, and not residing in a dementia unit.

摘要

一项针对 137 名未接受抗生素治疗的养老院居民(其中 44 名居民感染了多重耐药菌)的巢式病例对照研究表明,影响肠道微生物组的胃肠道药物、医护人员的访视次数、压疮以及未居住在痴呆病房与感染的相关性较高。

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本文引用的文献

1
Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications.系统评价:非抗生素处方药诱导的人类肠道菌群失调。
Aliment Pharmacol Ther. 2018 Feb;47(3):332-345. doi: 10.1111/apt.14451. Epub 2017 Dec 5.
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Lessons from the Environmental Antibiotic Resistome.环境抗生素耐药组的启示
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Transmission of Methicillin-Resistant Staphylococcus aureus (MRSA) to Healthcare Worker Gowns and Gloves During Care of Nursing Home Residents.在护理养老院居民期间,耐甲氧西林金黄色葡萄球菌(MRSA)传播至医护人员的工作服和手套。
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Infection management and multidrug-resistant organisms in nursing home residents with advanced dementia.养老院中患有晚期痴呆症的居民的感染管理和多重耐药菌。
JAMA Intern Med. 2014 Oct;174(10):1660-7. doi: 10.1001/jamainternmed.2014.3918.
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Microbiota-mediated colonization resistance against intestinal pathogens.微生物群介导的定植抵抗肠道病原体。
Nat Rev Immunol. 2013 Nov;13(11):790-801. doi: 10.1038/nri3535. Epub 2013 Oct 7.
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The study of pathogen resistance and antimicrobial use in dementia: study design and methodology.痴呆症中病原体耐药性和抗菌药物使用的研究:研究设计与方法。
Arch Gerontol Geriatr. 2013 Jan-Feb;56(1):16-22. doi: 10.1016/j.archger.2012.08.001. Epub 2012 Aug 25.
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Diagnostic accuracy of surveillance cultures to detect gastrointestinal colonization with multidrug-resistant gram-negative bacteria.监测培养物检测多重耐药革兰氏阴性菌胃肠道定植的诊断准确性。
Am J Infect Control. 2012 Jun;40(5):474-6. doi: 10.1016/j.ajic.2011.06.011. Epub 2011 Sep 17.
8
Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation.人类远端肠道微生物组对重复抗生素扰动的不完全恢复和个体化反应。
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1(Suppl 1):4554-61. doi: 10.1073/pnas.1000087107. Epub 2010 Sep 16.
9
Multidrug-resistant gram-negative bacteria at a long-term care facility: assessment of residents, healthcare workers, and inanimate surfaces.长期护理机构的耐多药革兰氏阴性菌:对居民、医护人员和无生命表面的评估。
Infect Control Hosp Epidemiol. 2009 Dec;30(12):1172-9. doi: 10.1086/648453.
10
High rate of false-negative results of the rectal swab culture method in detection of gastrointestinal colonization with vancomycin-resistant enterococci.直肠拭子培养法检测耐万古霉素肠球菌胃肠道定植时假阴性结果的发生率较高。
Clin Infect Dis. 2002 Jan 15;34(2):167-72. doi: 10.1086/338234. Epub 2001 Dec 4.