Visser Marike, Walz Heather, Shrader Stephanie, Koehler Jey, Bellah Jamie
J Avian Med Surg. 2018 Mar;32(1):40-44. doi: 10.1647/2016-188.
An adult bald eagle ( Haliaeetus leucocephalus) presented for nystagmus and an inability to fly. On physical examination, the eagle was open-mouth breathing and tachycardic at 200 beats per minute, had a wrinkled cere and sunken eyes, and was an estimated 10% dehydrated. Additionally, the eagle was extremely weak, with neurologic abnormalities including bilateral proprioceptive deficits, nystagmus, and no pupillary light reflex in the left eye. Despite aggressive treatment, the eagle continued to decline rapidly and subsequently died. On histologic examination, diffuse and widespread infiltration of neoplastic lymphocytes was present in the brain, optic nerves, and pecten. Immunohistochemical PAX-5 labeling confirmed B-cell lymphoma confined to the eye and nervous system. Test results for select avian retroviruses, Marek's disease, West Nile virus, avian influenza viruses, and Mycoplasma were negative. To our knowledge, this is the first report of B-cell lymphoma in a bald eagle. Although rare, this condition is a differential diagnosis in cases of neurologic or ocular diseases in birds.
一只成年白头海雕（Haliaeetus leucocephalus）因眼球震颤和无法飞行前来就诊。体格检查时，这只白头海雕张嘴呼吸，心率达每分钟200次，蜡膜起皱且眼睛凹陷，估计脱水10%。此外，这只白头海雕极度虚弱，存在神经学异常，包括双侧本体感觉缺陷、眼球震颤，且左眼无瞳孔对光反射。尽管进行了积极治疗，但这只白头海雕病情仍迅速恶化，最终死亡。组织学检查显示，大脑、视神经和栉膜中有弥漫性且广泛的肿瘤性淋巴细胞浸润。免疫组化PAX - 5标记证实为局限于眼部和神经系统的B细胞淋巴瘤。针对特定禽逆转录病毒、马立克氏病、西尼罗河病毒、禽流感病毒和支原体的检测结果均为阴性。据我们所知，这是白头海雕中B细胞淋巴瘤的首例报告。尽管这种情况罕见，但在鸟类神经或眼部疾病病例中是一种鉴别诊断。
