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橄榄油酚类化合物通过调节成骨细胞基因表达发挥骨保护作用。

Bone Protective Effect of Extra-Virgin Olive Oil Phenolic Compounds by Modulating Osteoblast Gene Expression.

机构信息

Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016 Granada, Spain.

Instituto Investigación Biosanitaria, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012 Granada, Spain.

出版信息

Nutrients. 2019 Jul 25;11(8):1722. doi: 10.3390/nu11081722.

DOI:10.3390/nu11081722
PMID:31349732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6722737/
Abstract

The phenolic compounds of extra-virgin olive oil can act at various levels to protect individuals against cardiovascular and neurodegenerative diseases, cancer, and osteoporosis, among others. Polyphenols in extra-virgin olive oil can stimulate the proliferation of osteoblasts, modify their antigen profile, and promote alkaline phosphatase synthesis. The objective of this work was to determine the effect of different extra-virgin olive oil phenolic compounds on the gene expression of osteoblast-related markers. The cells of the MG63 osteoblast line were cultured for 24 h with 10 M of the phenolic compounds ferulic acid, caffeic acid, coumaric acid, apigenin, or luteolin. The expression of studied markers was quantified using quantitative real-time polymerase chain reaction (q-RT-PCR). The expression by MG63 osteoblasts of growth and differentiation/maturation markers was modified after 24 h of treatment with 10 M of the phenolic compounds under study, most of which increased the gene expression of the transforming growth factor β1 (TGF-β1), TGF-β receptor 1,2 and 3 (TGF-βR1, TGF-βR2, TGF-βR3), bone morphogenetic protein 2 and 7 (BMP2, BMP7), run-related transcription factor 2 (RUNX-2), Alkaline phosphatase (ALP), Osteocalcin (OSC), Osterix (OSX), Collagen type I (Col-I) and osteoprotegerin (OPN). The extra-virgin olive oil phenolic compounds may have a beneficial effect on bone by modulating osteoblast physiology, which would support their protective effect against bone pathologies.

摘要

特级初榨橄榄油中的酚类化合物可以在多个层面上保护个体免受心血管和神经退行性疾病、癌症和骨质疏松症等疾病的侵害。特级初榨橄榄油中的多酚可以刺激成骨细胞增殖、改变其抗原谱，并促进碱性磷酸酶的合成。本研究的目的是确定不同特级初榨橄榄油酚类化合物对成骨细胞相关标志物基因表达的影响。将 MG63 成骨细胞系的细胞在含有 10 M 阿魏酸、咖啡酸、香豆酸、芹菜素或木樨草素的酚类化合物中培养 24 小时。使用定量实时聚合酶链反应 (q-RT-PCR) 定量研究标记物的表达。经过 24 小时的处理，MG63 成骨细胞中研究的标记物的生长和分化/成熟标记物的表达发生改变，其中大多数增加了转化生长因子 β1（TGF-β1）、TGF-β 受体 1、2 和 3（TGF-βR1、TGF-βR2、TGF-βR3）、骨形态发生蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、成骨转录因子 2（RUNX-2）、碱性磷酸酶（ALP）、骨钙素（OSC）、骨形成蛋白 2 和 7（BMP2、BMP7）、骨连接蛋白（OPN）的基因表达增加。特级初榨橄榄油中的酚类化合物可能通过调节成骨细胞生理学对骨骼产生有益影响，从而支持其对骨骼疾病的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/2725d71512bb/nutrients-11-01722-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/de91883afa79/nutrients-11-01722-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/3590977e677d/nutrients-11-01722-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/f6c8d84f1136/nutrients-11-01722-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/2725d71512bb/nutrients-11-01722-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/de91883afa79/nutrients-11-01722-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/3590977e677d/nutrients-11-01722-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/f6c8d84f1136/nutrients-11-01722-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e2/6722737/2725d71512bb/nutrients-11-01722-g004.jpg

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