Hashmi Atif Ali, Faraz Mahrukh, Nauman Zareeha, Qureshi Muhammad Usman, Hashmi Shumaila Kanwal, Waseem Hira Fatima, Edhi Muhammad Muzzammil, Faridi Naveen, Khan Amir
Department of Pathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.
Department of Pathology, Aga Khan University, Karachi, Pakistan.
BMC Res Notes. 2018 Jul 11;11(1):457. doi: 10.1186/s13104-018-3562-8.
Gastrointestinal stromal tumors (GISTs) are rare tumors of gastrointestinal tract, prognosis of which largely depends upon histopathologic characteristics of resection specimens, which were not widely studied in our population. Therefore we aimed to evaluate the histopathologic characteristics of GISTs in our population and their prognostic grouping according to college of American pathologist's guidelines.
Mean age of patients was 53.4 years (18-71 years). 92% of cases were of primary GISTs and stomach was the most common site (57.7%). 75% of cases were of spindle cell morphology and 53.8% belonged to high risk prognostic group. Comparison of stomach and intestinal GISTs showed that intestinal GISTs were found to be of high grade (70%) and of high risk prognostic group (75 and 80%) compared to stomach GISTs (43% were of high risk prognostic group), however this finding was not statistically significant. GISTs are infrequent gastrointestinal tumors but early diagnosis and identification of adverse histological features are key to successful treatment. We found a large majority of GISTs to be located in stomach, however intestinal GISTs were found more likely to be associated with adverse prognostic parameters. However more large scale studies are warranted to establish this finding.
胃肠道间质瘤（GISTs）是胃肠道的罕见肿瘤，其预后很大程度上取决于切除标本的组织病理学特征，而在我们的研究人群中对此研究并不广泛。因此，我们旨在评估我们研究人群中GISTs的组织病理学特征及其根据美国病理学家学会指南的预后分组。
患者的平均年龄为53.4岁（18 - 71岁）。92%的病例为原发性GISTs，胃是最常见的部位（57.7%）。75%的病例为梭形细胞形态，53.8%属于高风险预后组。胃和肠道GISTs的比较显示，与胃GISTs（43%为高风险预后组）相比，肠道GISTs的分级较高（70%）且属于高风险预后组（75%和80%），然而这一发现无统计学意义。GISTs是罕见的胃肠道肿瘤，但早期诊断和识别不良组织学特征是成功治疗的关键。我们发现大多数GISTs位于胃，但肠道GISTs更可能与不良预后参数相关。然而，需要更多大规模研究来证实这一发现。
