Suzuki Atsushi, Kurihara Yasuyuki, Saga Yumiko
Interdisciplinary Research Center, Yokohama National University 79-1 Tokiwadai, Hodogaya 240-8501 Yokohama Kanagawa Japan.
Department of Environment and Natural Sciences Graduate School of Environment and Information Sciences, Yokohama National University 79-7 Tokiwadai, Hodogaya 240-8501 Yokohama Kanagawa Japan.
Reprod Med Biol. 2011 Dec 23;11(2):73-77. doi: 10.1007/s12522-011-0115-4. eCollection 2012 Apr.
Approximately 10% of Japanese couples who want to have children experience infertility, and the majority of these individuals have either abnormal egg cell or abnormal sperm development. In addition, currently, there is a low birth rate in many parts of the developed world; therefore, it is critical to elucidate the mechanisms of germ cell development. Thus, the study of assisted reproductive technologies has scientific significance, and is a key to solving infertility problems. This review summarizes the development of mouse germ cells, particularly focusing on the role of Nanos genes, which are essential for the development of mouse germ cells and have been identified as genes that are involved in human infertility. We also briefly introduce a study in which this information is applied to assisted reproductive technologies.
大约10%想要孩子的日本夫妇面临不孕不育问题，其中大多数人的卵细胞或精子发育异常。此外，目前在许多发达国家的部分地区出生率较低；因此，阐明生殖细胞发育机制至关重要。因此，辅助生殖技术的研究具有科学意义，是解决不孕不育问题的关键。这篇综述总结了小鼠生殖细胞的发育，特别关注Nanos基因的作用，该基因对小鼠生殖细胞的发育至关重要，并且已被确定为与人类不孕不育有关的基因。我们还简要介绍了一项将这些信息应用于辅助生殖技术的研究。
