Qin Yingying, Zhao Han, Kovanci Ertug, Simpson Joe Leigh, Chen Zi-Jiang, Rajkovic Aleksandar
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China.
Fertil Steril. 2007 Nov;88(5):1465-7. doi: 10.1016/j.fertnstert.2007.01.020. Epub 2007 Apr 5.
NANOS3 encodes an RNA-binding protein and has a conserved function in germ cell development. Our objective was to investigate whether mutations in NANOS3 were present in Chinese and Caucasian women with premature ovarian failure. A known synonymous single-nucleotide polymorphism (rs 2016163) in exon 1 was identified through sequencing 80 Chinese and 88 Caucasian women with premature ovarian failure. No additional single-nucleotide polymorphisms or mutations were found in exons encoding for NANOS3. Our findings suggest that mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure.
NANOS3编码一种RNA结合蛋白，在生殖细胞发育中具有保守功能。我们的目的是调查中国和高加索地区卵巢早衰女性中是否存在NANOS3突变。通过对80名中国卵巢早衰女性和88名高加索卵巢早衰女性进行测序，在第1外显子中鉴定出一个已知的同义单核苷酸多态性（rs 2016163）。在编码NANOS3的外显子中未发现其他单核苷酸多态性或突变。我们的研究结果表明，在患有卵巢早衰的中国和高加索女性中，NANOS3外显子的突变很少见。
