Shibahara Hiroaki, Kikuchi Kumiko, Shiraishi Yasuko, Suzuki Mitsuaki, Shigeta Minoru, Koyama Koji
Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi.
Department of Obstetrics and Gynecology, Kinki Central Hospital, Hyogo and.
Reprod Med Biol. 2003 Sep 26;2(3):105-108. doi: 10.1046/j.1445-5781.2003.00027.x. eCollection 2003 Sep.
The factors that affect sperm immobilizing antibody production in some women are not fully understood. This study was performed to investigate if production of sperm immobilizing antibodies in women is associated with their husbands' sperm count. The sperm immobilization test (SIT) was performed on 221 infertile women whose husbands had normal semen characteristics according to the criteria by WHO; 160 patients were treated by intracytoplasmic sperm injection (ICSI) because of poor semen characteristics, and 1013 virgin female children acted as the controls. A significant difference of the incidence in SIT was observed between the virgin female children and the women whose husbands had a normal sperm count ( < 0.0001). There was also a significant difference of the incidence in SIT between the women treated by intracytoplasmic sperm injection (ICSI) because of a severe male factor and those whose husbands had a normal sperm count ( < 0.05). These results indicate that production of sperm immobilizing antibodies in women begins after they have been exposed to a large enough amount of sperm. However, the precise amount of sperm required to produce the antibodies is not clarified by the present study. (Reprod Med Biol 2003; : 105-108).
某些女性体内影响精子制动抗体产生的因素尚未完全明确。本研究旨在调查女性体内精子制动抗体的产生是否与其丈夫的精子计数有关。对221名不育女性进行了精子制动试验（SIT），这些女性的丈夫精液特征根据世界卫生组织标准属于正常；160名患者因精液特征不佳接受了卵胞浆内单精子注射（ICSI）治疗，1013名未成年处女作为对照。在未成年处女与丈夫精子计数正常的女性之间，观察到SIT发生率存在显著差异（<0.0001）。因男性因素严重而接受卵胞浆内单精子注射（ICSI）治疗的女性与丈夫精子计数正常的女性之间，SIT发生率也存在显著差异（<0.05）。这些结果表明，女性体内精子制动抗体的产生始于她们接触到足够数量的精子之后。然而，本研究并未阐明产生这些抗体所需的精确精子数量。（《生殖医学与生物学》2003年；：105 - 108）
