A successful pregnancy and delivery outcome for a 46-year-old woman following fertilization.

Decreased conception rate with advanced maternal age has been well demonstrated. Although this decline becomes apparent at 35 years of age, and accelerates rapidly in women over 40 years of age, we are able to report pregnancy and delivery case for a 46-year-old with fertilization and embryo transfer (IVF-ET). We report a rare case of a successful delivery of a healthy infant by a 46-year-old women following IVF-ET. She tried three times with conventional IVF and two times cryopreserved embryo transfer, but she failed to conceive. Low-dose dexamethasone was co-treated the last two times with IVF on the first day of the beginning menstrual cycle daily and continued until retrieval day. We obtained good quality embryos and she became pregnant at the sixth time of IVF which was carried out at the morula and early blastocyst stage. She finally conceived following co-treatment with low-dose dexamethasone. She delivered vaginally a single male infant with no congenital abnormalities at 40 weeks' (3416 g; 46, XY). We have demonstrated a successful pregnancy due to obtaining quality embryos using co-treatment low-dose dexamethasone and delivery outcome for a 46-year-old woman using IVF. (Reprod Med Biol 2004; : 39-42).