化学物质、食物和环境因素引起的表观遗传改变。
Epigenetic alteration by the chemical substances, food and environmental factors.
作者信息
Fukata Hideki, Mori Chisato
机构信息
Departments of Environmental Medical Science (SRL).
Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan.
出版信息
Reprod Med Biol. 2004 Aug 10;3(3):115-121. doi: 10.1111/j.1447-0578.2004.00066.x. eCollection 2004 Sep.
Epigenetic alteration is one of the most important mechanisms for gene regulation; however, it is not changes in gene function with DNA sequence changes. Recently, epigenetics were studied in the wide ranging fields of research. In the present review, we introduce recent studies on epigenetic alteration, especially DNA methylation, by chemical exposure, food intake and environmental factors. In addition, we introduced our results on alteration of DNA methylation by transient exposure of neonatal mice to diethylstilbestrol. As these data suggest that chemical exposure, food intake and environmental factors are responsible for epigenetic alteration, we insist the necessity of the new risk assessment focusing on epigenetic alteration. (Reprod Med Biol 2004; : 115-121).
表观遗传改变是基因调控的最重要机制之一；然而，它并非是随着DNA序列改变而发生的基因功能变化。最近，表观遗传学在广泛的研究领域中得到了研究。在本综述中，我们介绍了关于化学暴露、食物摄入和环境因素引起的表观遗传改变，尤其是DNA甲基化的最新研究。此外，我们还介绍了新生小鼠短暂暴露于己烯雌酚后DNA甲基化改变的研究结果。由于这些数据表明化学暴露、食物摄入和环境因素是表观遗传改变的原因，我们坚持认为有必要开展侧重于表观遗传改变的新的风险评估。（《生殖医学与生物学》2004年；：115 - 121）
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