Qin Tengfei, Zhang Xiaoping, Guo Ting, Yang Ting, Gao Yahui, Hao Wei, Xiao XiangFen
Henan Collaborative Innovation Center of Modern Biological Breeding, Henan Institute of Sciences and Technology, Xinxiang, China.
School of Medical Science, Chifeng University, Chifeng, China.
Front Genet. 2021 Jan 11;11:618966. doi: 10.3389/fgene.2020.618966. eCollection 2020.
Bisphenol A (BPA) is extensively used in plastic products and epoxy resins. The epigenetic response to the environmental chemical BPA was involved in multiple dysfunctional categories, such as cancer, the reproductive system, metabolism, pubertal development, peripheral arterial disease, infant and childhood growth, and neurodevelopment outcomes. In this mini-review, we described the recent progress of the epigenetic effects of the environmental chemical BPA, including DNA methylation, histone methylation, and toxic epigenomics. Notably, the histone modification changes under BPA exposure are summarized in this review. DNA methylation accompanied by transcriptional changes in key genes affected by BPA exposure is related to various processes, including neural development, cancer pathways, and generational transmission. In addition, BPA could also affect histone modifications in many species, such as humans, rats, and zebrafish. Finally, we reviewed recent studies of the toxico-epigenomics approach to reveal the epigenetic effect of BPA exposure genome-wide.
双酚A(BPA)广泛应用于塑料制品和环氧树脂中。对环境化学物质双酚A的表观遗传反应涉及多个功能失调类别,如癌症、生殖系统、新陈代谢、青春期发育、外周动脉疾病、婴幼儿和儿童生长以及神经发育结果。在本综述中,我们描述了环境化学物质双酚A表观遗传效应的最新进展,包括DNA甲基化、组蛋白甲基化和毒性表观基因组学。值得注意的是,本综述总结了双酚A暴露下的组蛋白修饰变化。双酚A暴露影响的关键基因的DNA甲基化伴随转录变化与包括神经发育、癌症通路和代际传递在内的各种过程有关。此外,双酚A还可影响许多物种的组蛋白修饰,如人类、大鼠和斑马鱼。最后,我们回顾了最近关于毒性表观基因组学方法的研究,以揭示双酚A暴露在全基因组范围内的表观遗传效应。