Kawamura Toshihiro, Mori Michiko, Arichi Akane, Tajima Yuko, Karasawa Yasuhiro, Suga Kahori, Ikumi Sachiko, Ishikawa Seika, Kawamura Makiko
Denentoshi Ladies' Clinic, Reproductive Medical Center, Yokohama-shi, Kanagawa, Japan.
Reprod Med Biol. 2005 Jul 28;4(3):197-201. doi: 10.1111/j.1447-0578.2005.00105.x. eCollection 2005 Sep.
Blastocysts are reportedly suitable for preventing multiple pregnancies as a result of the high implantation rate per embryo. The present study compared clinical results for elective single embryo transfer (ET) between blastocysts and cleavage-stage embryos in order to ascertain the usefulness of blastocyst culturing in single ET. Between January 2002 and December 2004, conventional fertilization ET and/or intracytoplasmic sperm injection was carried out for single ET in 86 cycles, to prevent multiple pregnancies (for medical reasons or because of patient wishes). Among the 80 cycles in which a fresh embryo was transferred, pregnancy/implantation rates per ET were 35.3% for day 2/3 ET and 50.0% for day 5 ET, and pregnancy/implantation rates per oocyte retrieval were 35.3% for day 2/3 ET and 44.2% for day 5 ET. Ongoing pregnancy/delivery rates per oocyte retrieval were 32.4% for day 2/3 ET and 38.5% for day 5 ET. Monozygotic twinning occurred in one case of day 5 ET. Pregnancy rates per single ET tended to be higher for day 5 ET than for day 2/3 ET. However, no marked differences were identified in ongoing pregnancy/delivery rates per oocyte retrieval between groups. (Reprod Med Biol 2005; : 197-201).
据报道，由于每个胚胎的着床率高，囊胚适合用于预防多胎妊娠。本研究比较了囊胚和卵裂期胚胎在选择性单胚胎移植（ET）中的临床结果，以确定囊胚培养在单胚胎移植中的实用性。在2002年1月至2004年12月期间，为预防多胎妊娠（出于医学原因或患者意愿），对86个周期进行了常规受精ET和/或卵胞浆内单精子注射以进行单胚胎移植。在80个移植新鲜胚胎的周期中，第2/3天ET的每次ET妊娠/着床率为35.3%，第5天ET为50.0%，每次取卵的妊娠/着床率第2/3天ET为35.3%，第5天ET为44.2%。每次取卵的持续妊娠/分娩率第2/3天ET为32.4%，第5天ET为38.5%。第5天ET有1例发生单卵双胎。第5天ET的每次单胚胎移植妊娠率往往高于第2/3天ET。然而，两组间每次取卵的持续妊娠/分娩率未发现明显差异。（《生殖医学与生物学》2005年；：197 - 201）
