Nobuyoshi M, Kimura T, Nosaka H, Mioka S, Ueno K, Yokoi H, Hamasaki N, Horiuchi H, Ohishi H
Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
J Am Coll Cardiol. 1988 Sep;12(3):616-23. doi: 10.1016/s0735-1097(88)80046-9.
To further understand the temporal mode and mechanisms of coronary restenosis, 229 patients were studied by prospective angiographic follow-up on day 1 and at 1, 3 and 6 months and 1 year after successful percutaneous transluminal coronary angioplasty. Quantitative measurement of coronary stenosis was achieved by cinevideodensitometric analysis. Actuarial restenosis rate was 12.7% at 1 month, 43.0% at 3 months, 49.4% at 6 months and 52.5% at 1 year. In 219 patients followed up for greater than or equal to 3 months, mean stenosis diameter was 1.91 +/- 0.53 mm immediately after coronary angioplasty, 1.72 +/- 0.52 mm on day 1, 1.86 +/- 0.58 mm at 1 month and 1.43 +/- 0.67 mm at 3 months. In 149 patients followed up for greater than or equal to 6 months, mean stenosis diameter was 1.66 +/- 0.58 mm at 3 months and 1.66 +/- 0.62 mm at 6 months. In 73 patients followed up for 1 year, mean stenosis diameter was 1.65 +/- 0.56 mm at 6 months and 1.66 +/- 0.57 mm at 1 year. Thus, stenosis diameter decreased markedly between 1 month and 3 months after coronary angioplasty and reached a plateau thereafter. In conclusion, restenosis is most prevalent between 1 and 3 months and rarely occurs beyond 3 months after coronary angioplasty.
为进一步了解冠状动脉再狭窄的时间模式及机制，对229例患者进行了前瞻性血管造影随访，随访时间为成功实施经皮腔内冠状动脉成形术后第1天、1个月、3个月、6个月及1年。通过电影视频密度分析对冠状动脉狭窄进行定量测量。1个月时的精算再狭窄率为12.7%，3个月时为43.0%，6个月时为49.4%，1年时为52.5%。在219例随访时间大于或等于3个月的患者中，冠状动脉成形术后即刻平均狭窄直径为1.91±0.53mm，第1天为1.72±0.52mm，1个月时为1.86±0.58mm，3个月时为1.43±0.67mm。在149例随访时间大于或等于6个月的患者中，3个月时平均狭窄直径为1.66±0.58mm，6个月时为1.66±0.62mm。在73例随访1年的患者中，6个月时平均狭窄直径为1.65±0.56mm，1年时为1.66±0.57mm。因此，冠状动脉成形术后1个月至3个月期间狭窄直径明显减小，此后趋于平稳。总之，再狭窄在冠状动脉成形术后1至3个月最为常见，3个月后很少发生。
