Bhaumik Pradip, Debnath Kalyan
Department of Medicine, Agartala Government Medical College, Agartala, Tripura, India.
Indira Gandhi Memorial Hospital, Agartala, Tripura, India.
Euroasian J Hepatogastroenterol. 2014 Jul-Dec;4(2):79-82. doi: 10.5005/jp-journals-10018-1106. Epub 2014 Jul 28.
Blood-borne viral infections, like hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), are most common during blood transfusion. Morbidity and mortality resulting from the transfusion of infected blood have far reaching consequences not only for the recipients themselves but also for their families, communities and the wider society.
The study was designed to determine the prevalence of HBV, HCV and HIV among voluntary and replacement blood donors of Tripura, India, and to study the trends of HBV, HCV and HIV infections in the population.
This study is a retrospective cross-sectional study. The data was collected for consecutive 8 years from 2005 to 2013. Analyses were done in respect of total blood collection and HBV, HCV and HIV infections among the donors.
Among all donors, 91.8% was voluntary donors and 8.2% was replacement donors. The average HBV, HCV and HIV positivity was 1.2% (95% CI: 1.155-1.255), 0.109% (95% CI: 0.0950.125) and 0.093% (95% CI: 0.080-0.108) respectively. Among these, HBV seropositivity was 1.19% among voluntary donors and 1.33% among replacement donors and, in case of HCV and HIV, the seropositivity among voluntary and replacement donors were 0.109%, 0.11% and 0.089%, 0.145% respectively. HBV positivity was reduced in 8 years, whereas those of HCV and HIV remain unchanged.
The most important observation of this study is gradual decrease in prevalence of HBV (p = 0.0018), whereas change in prevalence of HCV and HIV was not statistically significant. This might be due to mass hepatitis B vaccination program in Tripura. Bhaumik P, Debnath K. Prevalence of Blood-Borne Viral Infections among Blood Donors of Tripura. Euroasian J Hepato-Gastroenterol 2014;4(2):79-82.
血源性病毒感染，如乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV），在输血过程中最为常见。输注受感染血液导致的发病率和死亡率不仅对受血者自身，而且对其家庭、社区及更广泛的社会都产生深远影响。
本研究旨在确定印度特里普拉邦自愿献血者和替代献血者中HBV、HCV和HIV的流行率，并研究该人群中HBV、HCV和HIV感染的趋势。
本研究为回顾性横断面研究。收集了2005年至2013年连续8年的数据。对献血总量以及献血者中的HBV、HCV和HIV感染情况进行了分析。
在所有献血者中，91.8%为自愿献血者，8.2%为替代献血者。HBV、HCV和HIV的平均阳性率分别为1.2%（95%可信区间：1.155 - 1.255）、0.109%（95%可信区间：0.095 - 0.125）和0.093%（95%可信区间：0.080 - 0.108）。其中，自愿献血者中HBV血清阳性率为1.19%，替代献血者中为1.33%；对于HCV和HIV，自愿献血者和替代献血者中的血清阳性率分别为0.109%、0.11%和0.089%、0.145%。8年间HBV阳性率有所下降，而HCV和HIV的阳性率保持不变。
本研究最重要的观察结果是HBV流行率逐渐下降（p = 0.0018），而HCV和HIV流行率的变化无统计学意义。这可能归因于特里普拉邦的大规模乙肝疫苗接种计划。鲍米克P，德布纳特K。特里普拉邦献血者血源性病毒感染的流行率。《欧亚肝脏胃肠病学杂志》2014年；4(2)：79 - 82。
