Yeşiltepe Mutlu Gül, Hatun Şükrü
Koç University Hospital, Clinic of Pediatric Endocrinology and Diabetes, İstanbul, Turkey
Koç University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, İstanbul, Turkey
J Clin Res Pediatr Endocrinol. 2018 Nov 29;10(4):301-306. doi: 10.4274/jcrpe.0012. Epub 2018 Apr 27.
In recent years, the increase in interest and use of vitamin D has been attributed mainly to the extra-skeletal effects of vitamin D and confusion about normal reference values for serum 25-hydroxy vitamin D (25-OHD). However, The Institute of Medicine, which determines daily intake of nutrients, vitamins and minerals in the United States, emphasizes that there is no additional benefit of having a 25-OHD level above 20 ng/mL in terms of parathyroid hormone suppression, calcium absorption and “fall risk”. Taking into consideration that there has not been a significant increase in vitamin D deficiency and related conditions in Turkey over the past five years, it is not hard to suppose that this increased interest is due to doctors, using mass media platforms, who have made claims that vitamin D is a “panacea”. This paper aims to answer some frequently asked questions such as the threshold values recommended for the evaluation of vitamin D status, the clinical indications for measuring 25-OHD and suggestions on the use of lifelong vitamin D starting from pregnancy.
近年来，维生素D的关注度和使用量增加主要归因于维生素D的骨骼外效应以及血清25-羟维生素D（25-OHD）正常参考值的混乱。然而，确定美国营养素、维生素和矿物质每日摄入量的医学研究所强调，就甲状旁腺激素抑制、钙吸收和“跌倒风险”而言，25-OHD水平高于20 ng/mL并无额外益处。考虑到过去五年土耳其维生素D缺乏及相关病症并未显著增加，不难推测这种关注度的提高是由于医生通过大众媒体平台宣称维生素D是一种“万灵药”。本文旨在回答一些常见问题，如评估维生素D状态推荐的阈值、测量25-OHD的临床指征以及从孕期开始终身补充维生素D的建议。
