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二氧化硒作为一种替代试剂用于芳基甲基酮的直接α-硒代酰胺化反应。

Selenium Dioxide As an Alternative Reagent for the Direct α-Selenoamidation of Aryl Methyl Ketones.

机构信息

Centre for Advanced Studies in Chemistry, Department of Chemistry , North-Eastern Hill University , Shillong 793022 , India.

出版信息

J Org Chem. 2018 May 18;83(10):5829-5835. doi: 10.1021/acs.joc.8b00558. Epub 2018 May 3.

DOI:10.1021/acs.joc.8b00558
PMID:29699390
Abstract

A general strategy for the preparation of N, N-dialkyl-2-oxo-2-arylethaneselenoamides is described. The single step method involves direct coupling of aryl methyl ketones with secondary amines and selenium dioxide in DMSO. The reactions proceeded smoothly at room temperature to provide a number of the α-oxo-selenoamides in good to excellent yields.

摘要

描述了一种制备 N，N-二烷基-2-氧代-2-芳基乙硒酰胺的一般策略。该单步方法涉及在 DMSO 中，芳基甲基酮与仲胺和二氧化硒的直接偶联。反应在室温下顺利进行，以良好至优异的收率得到了许多α-氧代-硒代酰胺。

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