从酮类化合物一锅法不对称合成叔丁基亚磺酰基保护胺的任意一种非对映异构体。
One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones.
作者信息
Tanuwidjaja Jessica, Peltier Hillary M, Ellman Jonathan A
机构信息
Department of Chemistry, University of California, Berkeley, California 94720, USA.
出版信息
J Org Chem. 2007 Jan 19;72(2):626-9. doi: 10.1021/jo0616512.
PMID:17221983
Abstract
A one-pot method for the asymmetric synthesis of tert-butanesulfinyl-protected amines is described. Condensation of aryl alkyl and dialkyl ketones with tert-butanesulfinamide followed by in situ reduction with the appropriate reagent provides either diastereomer of the sulfinamide products in good yields and with diastereomeric ratios of up to 99:1.
摘要
描述了一种用于不对称合成叔丁基亚磺酰基保护胺的一锅法。芳基烷基酮和二烷基酮与叔丁基亚磺酰胺缩合，然后用适当的试剂原位还原，可高产率地得到亚磺酰胺产物的任意一种非对映异构体，非对映体比例高达99:1。
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