Shangpliang O Risuklang, Wanniang Kmendashisha, Kshiar Baskhemlang, Marpna Ibakyntiew D, Lipon Tyrchain Mitre, Mizar Pushpak, Myrboh Bekington
Centre for Advanced Studies in Chemistry, Department of Chemistry, North-Eastern Hill University, Mawlai, Shillong 793022, India.
University of Southampton, Southampton SO17 1BJ, U.K.
ACS Omega. 2019 Mar 29;4(3):6035-6043. doi: 10.1021/acsomega.9b00361. eCollection 2019 Mar 31.
A novel approach has been developed for the synthesis of a wide range of α-ketoacetals by the reaction of alkyl/aryl methyl ketones and aliphatic alcohols in the presence of selenium dioxide catalyzed by -toluenesufonic acid. This method represents a general route to obtain a wide variety of α-ketoacetals in a simple, rapid, and practical manner. This approach is particularly attractive because of the easy availability of the starting materials, mild reaction temperature, and good yields of the products. The resulting α-ketoacetals are of much synthetic value as organic intermediates.
已经开发出一种新方法，用于在对甲苯磺酸催化下，由烷基/芳基甲基酮与脂肪醇在二氧化硒存在下反应合成多种α-酮缩醛。该方法是一种以简单、快速且实用的方式获得多种α-酮缩醛的通用途径。由于起始原料容易获得、反应温度温和且产物收率良好，这种方法特别具有吸引力。所得的α-酮缩醛作为有机中间体具有很高的合成价值。
