Emotional Brain BV, Almere, the Netherlands.
Emotional Brain BV, Almere, the Netherlands; Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, the Netherlands.
J Sex Med. 2018 May;15(5):722-731. doi: 10.1016/j.jsxm.2018.03.082.
Efficacy of on-demand drugs for women with hypoactive sexual desire disorder or female sexual interest/arousal disorder (FSIAD) should be assessed using a validated instrument that assesses the discrete sexual events during which the on-demand drug is taken, because this type of assessment is more proximate to an on-demand drug's efficacy compared to instruments that assess sexual function over longer periods of time.
The aim of this study was to assess the psychometric properties of the Dutch translation of the previously validated 11-item Sexual Event Diary (SED) for measuring sexual satisfaction and sexual functioning during discrete sexual events.
Psychometric assessment was performed on data of 1,840 SEDs from 139 women with hypoactive sexual desire disorder/FSIAD, collected during a randomized clinical cross-over trial conducted in the Netherlands.
Item scores of the SED at the event level, and at subject level, summarized item scores during the placebo run-in period (PRI) and active treatment period, and score changes from PRI to active treatment period.
Reliability and convergent validity were confirmed. All item scores showed the ability to discriminate between known groups. Larger mean score changes from PRI were observed in groups with known benefit from the medication, as compared to those with no benefit. Guyatt effect sizes ranged from 0.51-1.02, thereby demonstrating ability to detect change.
The Dutch version of the SED is an excellent instrument for assessing female sexual functioning and sexual satisfaction during discrete sexual events and for assessing these concepts over longer periods of time.
Data were collected in a randomized, well-controlled trial. The large number of data points gave high statistical power, and the results confirmed previous findings. However, care is needed when generalizing the SED's validity to other areas of research, eg, recreational drug use and sexual risky behaviors, since the current validation study has not used such data. Consistent with the US-English version, the Dutch version of the SED is a reliable, valid, and responsive instrument, and suitable for use in evaluating effects of on-demand drugs in women with FSIAD. van Nes Y, Bloemers J, Kessels R, et al. Psychometric Properties of the Sexual Event Diary in a Sample of Dutch Women With Female Sexual Interest/Arousal Disorder. J Sex Med 2018;15:722-731.
对于患有性欲低下障碍或女性性兴趣/唤起障碍（FSIAD）的女性，按需药物的疗效应该使用评估离散性事件的经过验证的工具进行评估，因为与评估较长时间内性功能的工具相比，这种评估更接近按需药物的疗效。
本研究旨在评估先前经过验证的 11 项性行为事件日记（SED）的荷兰语翻译版的心理测量学特性，以衡量离散性事件期间的性满意度和性功能。
在荷兰进行的一项随机临床交叉试验中，对 139 名患有性欲低下障碍/FSIAD 的女性的 1840 份 SED 数据进行了心理测量评估。
事件水平和受试者水平的 SED 项目得分，在安慰剂导入期（PRI）和活性治疗期的总结项目得分，以及从 PRI 到活性治疗期的得分变化。
数据是在一项随机、对照良好的试验中收集的。大量的数据点提供了较高的统计能力，结果证实了先前的发现。然而，当将 SED 的有效性推广到其他研究领域，例如娱乐性药物使用和性行为风险行为时，需要谨慎，因为目前的验证研究并未使用此类数据。与美国英语版一样，荷兰版的 SED 是一种可靠、有效和敏感的工具，适用于评估 FSIAD 女性对按需药物的疗效。
van Nes Y, Bloemers J, Kessels R, et al. 荷兰女性女性性兴趣/唤起障碍患者的性行为事件日记的心理测量特性。性医学杂志 2018;15:722-731.
