Department of Pharmacoeonomics and Policy, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, USA.
Department of Health Policy and Management, School of Public Health, University of California, Los Angeles, CA, USA; Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California, Los Angeles, CA, USA; RAND Corporation, Santa Monica, CA, USA.
Sex Med Rev. 2022 Jan;10(1):23-41. doi: 10.1016/j.sxmr.2021.07.003. Epub 2021 Sep 1.
Hypoactive Sexual Desire Disorder (HSDD) / Female Sexual Interest/Arousal Disorder (FSIAD) impacts health-related quality of life (HRQoL) of women and their partners, yet existing measures fail to adequately capture relevant concepts (ie, what is essential to measure including symptoms/impacts) important to women with HSDD/FSIAD.
To identify HRQoL tools used to assess women with HSDD/FSIAD, and to evaluate their psychometric properties (ie, reliability, validity, and responsiveness).
We conducted searches in PubMed, Embase and PsychINFO from June 5, 1989 to September 30, 2020 for studies in women with HSDD/FSIAD and psychometric analyses (English only). Principles of the Preferred Reporting Items for Systematic reviews and Meta-Analyses, the COnsensus-based Standards for the selection of health Measurement INstruments Risk of Bias Checklist and other psychometric criteria were applied. Based on this search, 56 papers were evaluated including 15 randomized-controlled trials, 11 observational/single arm/open label studies, and 30 psychometric studies.
Of the 18 measures identified, the Female Sexual Function Index (FSFI) and Female Sexual Distress Scale-Revised (FSDS-R) were included in most studies (> 50%). General HRQoL instruments were not used in any of the clinical trials; the SF-12, SF-36 and EQ-5D-5L were reported in two observational studies. No instruments achieved positive quality ratings across all psychometric criteria. The FSFI, FSDS-R, Sexual Event Diary (SED) and the Sexual Desire Relationship Distress Scale (SDRDS), were the only measures to receive a positive rating for content validity.
Reliable and valid HRQoL measures that include sexual desire and distress are needed to provide a more systematic and comprehensive assessment of HRQoL and treatment benefits in women with HSDD/FSIAD. While inferences about HRQoL are limited due to the lack of uniformity in concepts assessed and limited psychometric evaluation of these measures in women with HSDD/FSIAD, opportunities exist for the development of reliable and validated tools that comprehensively measure the most relevant and important concepts in women with HSDD/FSIAD. Lim-Watson MZ, Hays RD, Kingsberg S, et al. A systematic literature review of health-related quality of life measures for women with Hypoactive Sexual Desire Disorder and Female Sexual Interest/Arousal Disorder. Sex Med Rev 2022;10:23-41.
性欲低下障碍（HSDD）/女性性兴趣/唤起障碍（FSIAD）会影响女性及其伴侣的健康相关生活质量（HRQoL），但现有评估工具未能充分捕捉到 HSDD/FSIAD 女性相关的重要概念（即，哪些概念对于 HSDD/FSIAD 女性是重要的，需要进行评估）。
本研究旨在确定用于评估 HSDD/FSIAD 女性的 HRQoL 工具，并评估其心理测量学特性（即，信度、效度和反应度）。
我们对 1989 年 6 月 5 日至 2020 年 9 月 30 日在 PubMed、Embase 和 PsychINFO 中进行了与 HSDD/FSIAD 女性相关的研究和心理测量分析（仅英语）检索。本研究应用了系统评价和荟萃分析的首选报告项目的原则、健康测量工具选择的共识标准、风险偏倚检查表和其他心理测量标准。基于这一检索，评估了 56 篇论文，其中包括 15 项随机对照试验、11 项观察性/单臂/开放性标签研究和 30 项心理测量研究。
在所确定的 18 项措施中，女性性功能指数（FSFI）和女性性困扰量表修订版（FSDS-R）在大多数研究中（>50%）都有被使用。在任何临床试验中均未使用一般 HRQoL 工具；两项观察性研究报告了 SF-12、SF-36 和 EQ-5D-5L。没有任何工具在所有心理测量标准上都获得了积极的质量评分。FSFI、FSDS-R、性事件日记（SED）和性欲望关系困扰量表（SDRDS）是唯一获得内容效度阳性评分的措施。
需要可靠和有效的 HRQoL 措施，包括性欲和困扰，以提供更系统和全面的评估 HSDD/FSIAD 女性的 HRQoL 和治疗获益。由于在 HSDD/FSIAD 女性中评估的概念缺乏一致性，并且这些措施的心理测量评估有限，因此存在开发可靠和有效的工具的机会，这些工具可以全面测量 HSDD/FSIAD 女性中最相关和最重要的概念。Lim-Watson MZ、Hays RD、Kingsberg S 等人。性欲低下障碍和女性性兴趣/唤起障碍女性健康相关生活质量评估工具的系统文献综述。性医学评论 2022；10：23-41。
